HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	25723849
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1606
+	Hs
		919762 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HECW1_HUMAN (1-1606): 0: 1184: 100.00
+	Hs
		1294888 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		849411 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		919827 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		808052 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		808078 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		849451 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF2_HUMAN (1017-1606): 0: 646: 35.34
+	Hs
		849452 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF1_HUMAN (1034-1606): 0: 611: 33.82
+	Hs
		919782 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HACE1_HUMAN (1082-1600): 1.84e-165: 526: 31.13
+	Hs
		849311 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		UBE3A_HUMAN (1151-1605): 1.17e-159: 509: 28.39
+	Hs
		919710 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3A_HUMAN (1151-1605): 1.17e-159: 509: 28.39
+	Hs
		125808 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		125262 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		125335 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		849444 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		919860 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		849416 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		919834 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		849353 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71
+	Hs
		919765 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71