HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: TRI50 (Q86XT4)
E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)
Gene: TRIM50

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	31176697, 21143188, 32296183, unassigned1304
Identification Methods	pull down, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 487
+	Hs
		584907 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RO52_HUMAN (1-473): 6.68e-148: 433: 26.72
+	Hs
		1336390 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09
+	Hs
		1204911 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00
+	Hs
		537142 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI27_HUMAN (1-475): 2.7e-134: 399: 27.11
+	Hs
		536760 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI27_HUMAN (1-475): 2.7e-134: 399: 27.11
+	Hs
		849406 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI11_HUMAN (1-482): 8.18e-131: 389: 26.84
+	Hs
		849358 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI69_HUMAN (1-473): 6.11e-123: 369: 26.63
+	Hs
		849366 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI22_HUMAN (1-475): 1.16e-120: 364: 24.41
+	Hs
		135045 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI38_HUMAN (1-474): 4.59e-120: 361: 24.95
+	Hs
		135012 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI38_HUMAN (1-474): 4.59e-120: 361: 24.95
+	Hs
		1318719 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRIM5_HUMAN (1-475): 2.45e-116: 353: 25.00
+	Hs
		1377469 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI17_HUMAN (1-463): 4.08e-114: 346: 23.69
+	Hs
		1313765 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI62_HUMAN (9-470): 4.7e-113: 343: 27.97
+	Hs
		849429 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI62_HUMAN (9-470): 4.7e-113: 343: 27.97
+	Hs
		1354526 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI10_HUMAN (1-462): 2.58e-111: 339: 25.00
+	Hs
		849347 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI72_HUMAN (1-477): 4.48e-109: 333: 31.06
+	Hs
		1285831 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI43_HUMAN (10-457): 2.23e-107: 328: 19.12
+	Hs
		849399 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI43_HUMAN (10-457): 2.23e-107: 328: 19.12
+	Hs
		1357712 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI35_HUMAN (3-473): 6.13e-102: 316: 25.72
+	Hs
		849384 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI41_HUMAN (1-44): 3.64e-10: 64.1: 31.25