HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RN185 (Q96GF1)
E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)
Gene: RNF185

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	36966392, 32296183, 19549727, unassigned1304
Identification Methods	pull down, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 192
+	Hs
		1292368 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN185_HUMAN (1-192): 2.35e-56: 178: 100.00
+	Hs
		919826 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN185_HUMAN (1-192): 2.35e-56: 178: 100.00
+	Dm
		639411 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		Q9VXP1_DROME (15-192): 4.58e-51: 167: 58.43
+	Dm
		639398 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		Q8IR26_DROME (15-191): 8.57e-45: 151: 52.54
+	Hs
		1307272 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38
+	Hs
		849424 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38
+	Hs
		849314 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI26_HUMAN (26-132): 1.42e-27: 109: 23.48
+	Hs
		1336390 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80
+	Hs
		919712 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		TRI26_HUMAN (26-132): 1.42e-27: 109: 23.48
+	Hs
		849406 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI11_HUMAN (27-130): 9.09e-27: 107: 25.00
+	Hs
		584907 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RO52_HUMAN (26-144): 2e-26: 106: 20.17
+	Hs
		849366 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI22_HUMAN (32-155): 2.91e-26: 106: 18.75
+	Hs
		849453 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80
+	Hs
		919822 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		TRI11_HUMAN (27-130): 9.09e-27: 107: 25.00
+	Hs
		584923 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RO52_HUMAN (26-144): 2e-26: 106: 20.17
+	At
		715141 UBC9_ARATH (1-147): 8.78e-82: 238: 77.55		Q9LN67_ARATH (37-164): 1.58e-27: 105: 35.57
+	Hs
		1356614 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		AMFR_HUMAN (27-171): 2.12e-24: 101: 19.18
+	Hs
		849484 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		AMFR_HUMAN (27-171): 2.12e-24: 101: 19.18
+	Hs
		749252 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		BRCA1_HUMAN (38-88): 2.19e-11: 64: 35.29
+	Hs
		749339 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		BRCA1_HUMAN (38-88): 2.19e-11: 64: 35.29