HitPredict

Interactor 1: CCR2 (P51683)
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC receptor) (MCP-1 receptor) (CD antigen CD192)
Gene: CCR2

Interactor 2: CCL7 (Q03366)
C-C motif chemokine 7 (Intercrine/chemokine MARC) (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (Protein FIC) (Small-inducible cytokine A7)
Gene: CCL7

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	8662823
Identification Methods	pull down, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0002548 - monocyte chemotaxis GO:0006954 - inflammatory response GO:0007186 - G protein-coupled receptor signaling pathway GO:0031727 - CCR2 chemokine receptor binding GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Mm			1 97
+	Mm
		486358 CCR2_MOUSE (1-373): 3.17e-101: 305: 100.00		CCL2_MOUSE (1-97): 5.79e-33: 113: 45.46
+	Hs
		849723 CCR8_HUMAN (28-369): 8.38e-92: 280: 41.21		CCL18_HUMAN (1-92): 1.28e-27: 97.7: 28.26
+	Hs
		1305163 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL13_HUMAN (1-96): 1.28e-33: 113: 47.96
+	Hs
		783833 CCR2_HUMAN (15-342): 1.13e-84: 263: 76.52		CCL13_HUMAN (1-96): 1.28e-33: 113: 47.96
+	Hs
		607528 CCR8_HUMAN (28-369): 8.38e-92: 280: 41.21		CCL1_HUMAN (1-96): 1.24e-26: 95.4: 35.05
+	Hs
		945622 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL8_HUMAN (1-97): 7.65e-32: 108: 50.51
+	Hs
		783815 CCR2_HUMAN (15-342): 1.13e-84: 263: 76.52		CCL8_HUMAN (1-97): 7.65e-32: 108: 50.51
+	Hs
		945630 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL7_HUMAN (17-96): 5.29e-30: 104: 54.88
+	Hs
		528225 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL2_HUMAN (1-96): 1.4e-29: 103: 55.10
+	Hs
		783816 CCR2_HUMAN (15-342): 1.13e-84: 263: 76.52		CCL7_HUMAN (17-96): 5.29e-30: 104: 54.88
+	Hs
		528206 CCR2_HUMAN (15-342): 1.13e-84: 263: 76.52		CCL2_HUMAN (1-96): 1.4e-29: 103: 55.10
+	Hs
		849725 CCR8_HUMAN (28-369): 8.38e-92: 280: 41.21		CCL17_HUMAN (6-89): 8.91e-23: 85.8: 29.76
+	Hs
		825305 CX3C1_HUMAN (26-357): 3e-89: 274: 42.94		X3CL1_HUMAN (8-93): 6.62e-21: 86.5: 27.78
+	Hs
		180162 CCR8_HUMAN (28-369): 8.38e-92: 280: 41.21		CCL16_HUMAN (1-87): 2.24e-20: 80.4: 27.17
+	Hs
		802290 XCR1_HUMAN (28-348): 4.73e-86: 265: 34.78		XCL1_HUMAN (1-95): 1.57e-23: 88.1: 27.37
+	Hs
		528250 CXCR3_HUMAN (15-338): 1.37e-83: 260: 33.13		CCL5_HUMAN (1-91): 3.23e-24: 89.2: 35.87
+	Hs
		134312 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL21_HUMAN (17-97): 1.71e-20: 81.2: 29.76
+	Hs
		180160 CCR2_HUMAN (15-342): 1.13e-84: 263: 76.52		CCL16_HUMAN (1-87): 2.24e-20: 80.4: 27.17
+	Hs
		179471 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL25_HUMAN (8-93): 1.83e-19: 78.8: 25.81
+	Hs
		1306053 ACKR4_HUMAN (37-361): 2.1e-85: 264: 31.12		CCL19_HUMAN (17-96): 8.93e-20: 78.1: 24.39