HitPredict

Interactor 1: CLCN7 (P51798)
H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)
Gene: CLCN7

Interactor 2: OSTM1 (Q86WC4)
Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit)
Gene: OSTM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.910

The method score is based on:

Property	Details
Experiments	32851177, 33961781, 32749217, 35271311
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, 3D electron microscopy
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	OSTMP1~Voltage_CLC
Common GO terms	GO:0005765 - lysosomal membrane GO:0030321 - transepithelial chloride transport GO:0034707 - chloride channel complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	805
Hs

1	334

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024