HitPredict

Interactor 1: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	19801544, 21145461
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 913
+	Hs
		134895 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		853274 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		853594 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		134894 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		131434 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		238673 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		853593 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		134893 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		168634 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		131433 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		853273 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		853592 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		853272 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CUL1_HUMAN (213-913): 0: 778: 30.16