HitPredict

Interactor 1: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Hs			1 1912
+	Hs
		238679 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		134899 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		168636 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		853286 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		853580 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		131423 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		853257 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Dm
		283986 O76522_DROME (4-538): 1.87e-146: 432: 44.49		CHDM_DROME (1-1904): 0: 1364: 50.85
+	Hs
		229344 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		SMCA5_HUMAN (578-1624): 0: 791: 26.01
+	Hs
		658643 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Hs
		238743 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Mm
		1000155 IMA5_MOUSE (1-538): 1.75e-154: 453: 97.77		CHD8_MOUSE (254-1678): 0: 761: 25.10
+	Mm
		192636 IMA4_MOUSE (3-538): 1.37e-152: 448: 46.10		CHD8_MOUSE (254-1678): 0: 761: 25.10
+	Hs
		853720 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Hs
		134969 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Hs
		168673 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Mm
		853539 IMA1_MOUSE (3-538): 2.83e-147: 435: 44.18		CHD8_MOUSE (254-1678): 0: 761: 25.10
+	Hs
		853480 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Zm
		11289 A0A1D6FC42_MAIZE (4-538): 8.61e-154: 451: 51.29		A0A1D6IBX9_MAIZE (319-420): 7.71e-11: 69.8: 34.29
+	Zm
		12493 A0A1D6FMC0_MAIZE (4-538): 2.87e-151: 447: 47.96		A0A1D6IBX9_MAIZE (319-420): 7.71e-11: 69.8: 34.29