HitPredict

Interactor 1: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	24067372, 18187047
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 826
+	Hs
		238688 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		134908 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		168642 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		131446 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		238729 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		853691 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		168664 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		131501 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		238633 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		649071 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		168619 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		131380 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Dm
		1096495 Q9V455_DROME (4-538): 9.55e-147: 433: 44.49		SIMA_DROME (4-722): 1.28e-95: 329: 25.42