HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	18723680, 19559631
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 204 Hs			1 303
+	Mm
		957032 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		CASP7_MOUSE (1-303): 3.09e-159: 447: 82.18
+	Hs
		854844 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00
+	Hs
		788165 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Mm
		936917 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92
+	Hs
		854788 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		788166 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		854814 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CASPA_HUMAN (33-251): 4.8e-81: 256: 36.32
+	Hs
		667442 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CASP1_HUMAN (1-301): 8.45e-79: 246: 21.04