Protein: NAL12
NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)

Gene: NAL12, NLRP12
Organism: Homo sapiens
Interactions: 79
UniProt ID: P59046

Gene Ontology (top 5):
GO:0001818 - negative regulation of cytokine production
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

947366

M3K14
Mitogen-activated protein kinase kinase kinase 14

2

2

Small-scale

0.754

High

905534

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.665

High

947345

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

Small-scale

0.590

High

947355

PYDC2
Pyrin domain-containing protein 2

1

18

Small-scale

0.590

High

461325

HS90A
Heat shock protein HSP 90-alpha

2

12

Small-scale

0.584

High

379972

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

Small-scale

0.528

High

520797

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

Small-scale

0.528

High

289132

PRDM1
PR domain zinc finger protein 1

1

3

Small-scale

0.515

High

536854

HSP7C
Heat shock cognate 71 kDa protein

1

10

Small-scale

0.515

High

947346

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

High-throughput

0.515

High

947361

H2B1H
Histone H2B type 1-H

1

3

High-throughput

0.515

High

947380

FAF1
FAS-associated factor 1

1

6

Small-scale

0.508

High

473389

HCK
Tyrosine-protein kinase HCK

1

1

Small-scale

0.506

High

947381

T3JAM
TRAF3-interacting JNK-activating modulator

1

8

Small-scale

0.506

High

471541

CD14
Monocyte differentiation antigen CD14

1

0

Small-scale

0.494

High

947384

LRC42
Leucine-rich repeat-containing protein 42

1

0

Small-scale

0.494

High

226740

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

11

High-throughput

0.479

High

731141

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

761615

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

946091

MLF1
Myeloid leukemia factor 1

1

2

High-throughput

0.479

High

947343

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

947344

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.479

High

947347

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.479

High

947351

MLF2
Myeloid leukemia factor 2

1

2

High-throughput

0.479

High

947352

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.479

High

947354

Q53FC7
Heat shock 70 kDa protein 6

1

10

High-throughput

0.479

High

947356

Q6PK50
HSP90AB1 protein

1

14

High-throughput

0.479

High

947359

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

947362

Q96BE0
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

947367

TTC1
Tetratricopeptide repeat protein 1

1

8

High-throughput

0.479

High

947370

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

947372

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.479

High

947377

FKBPL
FK506-binding protein-like

1

9

High-throughput

0.479

High

947379

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

High-throughput

0.479

High

947382

SGT1
Protein SGT1 homolog

1

14

Small-scale

0.479

High

947342

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.458

High

123909

MYO1F
Unconventional myosin-If

1

8

Small-scale

0.457

High

321474

PRP6
Pre-mRNA-processing factor 6

1

2

Small-scale

0.457

High

391597

FRIH
Ferritin heavy chain

1

1

Small-scale

0.457

High

608519

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

Small-scale

0.457

High

637419

FLNA
Filamin-A

1

3

Small-scale

0.457

High

679122

DNJB1
DnaJ homolog subfamily B member 1

1

6

Small-scale

0.457

High

856615

BAG6
Large proline-rich protein BAG6

1

7

Small-scale

0.457

High

947337

ACTB
Actin, cytoplasmic 1

1

3

Small-scale

0.457

High

947338

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.457

High

947339

3BP2
SH3 domain-binding protein 2

1

1

Small-scale

0.457

High

947341

AK17A
A-kinase anchor protein 17A

1

2

Small-scale

0.457

High

947353

LEG9B
Galectin-9B

1

2

Small-scale

0.457

High

947363

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

Small-scale

0.457

High

947365

RANB9
Ran-binding protein 9

1

2

Small-scale

0.457

High

947373

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

2

Small-scale

0.457

High

947375

RNC
Ribonuclease 3

1

2

Small-scale

0.457

High

947376

UBQL2
Ubiquilin-2

1

5

Small-scale

0.457

High

947378

UBQL1
Ubiquilin-1

1

5

Small-scale

0.457

High

947383

TLN1
Talin-1

1

6

Small-scale

0.457

High

124290

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.438

High

212185

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

Small-scale

0.438

High

391694

MT2
Metallothionein-2

1

0

Small-scale

0.438

High

518774

IL8
Interleukin-8

1

0

Small-scale

0.438

High

578649

GLNA
Glutamine synthetase

1

0

Small-scale

0.438

High

658959

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

0

Small-scale

0.438

High

724379

COR1A
Coronin-1A

1

0

Small-scale

0.438

High

878644

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

Small-scale

0.438

High

947340

CAP1
Adenylyl cyclase-associated protein 1

1

0

Small-scale

0.438

High

947348

UBX2B
UBX domain-containing protein 2B

1

0

Small-scale

0.438

High

947349

DAZP2
DAZ-associated protein 2

1

0

Small-scale

0.438

High

947350

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.438

High

947364

SAT2
Thialysine N-epsilon-acetyltransferase

1

0

Small-scale

0.438

High

76513

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

11

High-throughput

0.437

High

947368

Q9BPW0
Serine/threonine-protein phosphatase

1

7

High-throughput

0.437

High

426014

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

1

Small-scale

0.417

High

772306

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

1

Small-scale

0.417

High

947358

URP2
Fermitin family homolog 3

1

2

Small-scale

0.417

High

947371

ZN426
Zinc finger protein 426

1

1

Small-scale

0.417

High

405187

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

Small-scale

0.238

Low

947357

CHSTF
Carbohydrate sulfotransferase 15

1

0

Small-scale

0.238

Low

947360

SCTM1
Secreted and transmembrane protein 1

1

0

Small-scale

0.238

Low

947369

WAC
WW domain-containing adapter protein with coiled-coil

1

0

Small-scale

0.238

Low

947374

AKIP1
A-kinase-interacting protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025