HitPredict

Interactor 1: VAV2 (P52735)
Guanine nucleotide exchange factor VAV2 (VAV-2)
Gene: VAV2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	12577067, 11606575
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~SH2, PH~SH3_1, RhoGEF~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005154 - epidermal growth factor receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 878 Hs			1 217
+	Mm
		1141129 VAV2_MOUSE (1-878): 0: 643: 94.76		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		924938 VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		548677 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		654982 VAV_MOUSE (1-875): 8.6e-174: 526: 47.76		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		412098 VAV2_HUMAN (1-878): 0: 658: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		924777 Q96D37_HUMAN (66-875): 3.75e-154: 473: 45.24		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411580 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337333 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		548628 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		411981 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		924870 ECT2_HUMAN (99-622): 1.95e-67: 243: 13.85		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411673 FGD1_HUMAN (103-618): 4.37e-71: 255: 16.46		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		224698 KALRN_HUMAN (164-650): 4.79e-62: 231: 15.81		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		557795 ECT2_HUMAN (99-622): 1.95e-67: 243: 13.85		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		522974 RGRF1_HUMAN (172-545): 3.04e-77: 275: 21.48		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		279830 TRIO_HUMAN (187-658): 6.64e-51: 197: 13.25		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		1078876 PREX1_HUMAN (180-534): 2.34e-69: 253: 24.61		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		412357 ECT2_HUMAN (99-622): 1.95e-67: 243: 13.85		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		442854 NGEF_HUMAN (41-541): 1.73e-67: 240: 15.12		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		224699 KALRN_HUMAN (164-650): 4.79e-62: 231: 15.81		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58