Protein: VAV2
Guanine nucleotide exchange factor VAV2 (VAV-2)

Gene: VAV2
Organism: Homo sapiens
Interactions: 92
UniProt ID: P52735

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001784 - phosphotyrosine residue binding
GO:0002768 - immune response-regulating cell surface receptor signaling pathway
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005154 - epidermal growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363013

EGFR
Epidermal growth factor receptor

7

20

Small-scale

0.951

High

913671

TITIN
Titin

2

5

High-throughput

0.801

High

913636

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.789

High

913638

3BP2
SH3 domain-binding protein 2

2

11

Small-scale

0.786

High

410727

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

641536

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

193238

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

849128

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.744

High

472029

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

913647

GAB1
GRB2-associated-binding protein 1

1

17

High-throughput

0.692

High

913642

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.691

High

913639

SRPK2
SRSF protein kinase 2

1

5

High-throughput

0.656

High

913689

STK24
Serine/threonine-protein kinase 24

1

20

High-throughput

0.656

High

913652

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

913663

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

651233

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.641

High

440455

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.621

High

411628

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

484084

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.618

High

908881

NEK3
Serine/threonine-protein kinase Nek3

1

13

Small-scale

0.618

High

913633

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

913634

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

913637

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

913659

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

913678

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

913643

CAV1
Caveolin-1

1

2

Small-scale

0.604

High

913679

MARH7
E3 ubiquitin-protein ligase MARCHF7

2

1

Small-scale

0.600

High

913632

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.590

High

913644

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

290237

TM1L1
TOM1-like protein 1

1

2

High-throughput

0.573

High

583969

CD19
B-lymphocyte antigen CD19

1

3

Small-scale

0.561

High

913684

S12A6
Solute carrier family 12 member 6

1

1

Small-scale

0.561

High

913687

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.553

High

519867

ANDR
Androgen receptor

1

17

High-throughput

0.536

High

913676

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

4

Small-scale

0.536

High

913677

TXNIP
Thioredoxin-interacting protein

1

4

Small-scale

0.536

High

725486

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.536

High

913641

SMAD3
Mothers against decapentaplegic homolog 3

1

4

Small-scale

0.515

High

216066

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

5

High-throughput

0.508

High

290898

PPM1B
Protein phosphatase 1B

1

2

High-throughput

0.508

High

326933

UBE4B
Ubiquitin conjugation factor E4 B

1

1

High-throughput

0.508

High

651123

CCNO
Cyclin-O

1

2

High-throughput

0.508

High

881839

TCPG
T-complex protein 1 subunit gamma

1

11

High-throughput

0.508

High

895897

F10A1
Hsc70-interacting protein

1

5

High-throughput

0.508

High

912819

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

16

High-throughput

0.508

High

913631

RD23A
UV excision repair protein RAD23 homolog A

1

10

High-throughput

0.508

High

913640

TCPB
T-complex protein 1 subunit beta

1

11

High-throughput

0.508

High

913651

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

14

High-throughput

0.508

High

913653

TRBP2
RISC-loading complex subunit TARBP2

1

3

High-throughput

0.508

High

913657

DJC21
DnaJ homolog subfamily C member 21

1

5

High-throughput

0.508

High

913658

CE170
Centrosomal protein of 170 kDa

1

13

High-throughput

0.508

High

913660

5MP2
eIF5-mimic protein 2

1

4

High-throughput

0.508

High

913662

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

12

High-throughput

0.508

High

913664

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

9

High-throughput

0.508

High

913665

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.508

High

913666

PNMA1
Paraneoplastic antigen Ma1

1

6

High-throughput

0.508

High

913668

IPO4
Importin-4

1

6

High-throughput

0.508

High

913669

PHF10
PHD finger protein 10

1

1

High-throughput

0.508

High

913673

HS105
Heat shock protein 105 kDa

1

14

High-throughput

0.508

High

913675

SRRT
Serrate RNA effector molecule homolog

1

3

High-throughput

0.508

High

913680

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

High-throughput

0.508

High

913686

CHMP3
Charged multivesicular body protein 3

1

3

High-throughput

0.508

High

913688

ARI1
E3 ubiquitin-protein ligase ARIH1

1

6

High-throughput

0.508

High

287446

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.486

High

402446

FUCO
Tissue alpha-L-fucosidase

1

0

High-throughput

0.486

High

881644

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.486

High

913645

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.486

High

913661

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.486

High

913674

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.486

High

913646

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.481

High

254096

CTND1
Catenin delta-1

1

14

Small-scale

0.479

High

353131

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

536802

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

591252

CD44
CD44 antigen

1

1

Small-scale

0.479

High

596945

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

694994

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

913635

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

913650

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

913685

XPO7
Exportin-7

1

10

High-throughput

0.479

High

155197

NCKP5
Nck-associated protein 5

1

7

High-throughput

0.464

High

913656

BRDT
Bromodomain testis-specific protein

1

7

High-throughput

0.464

High

913667

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

20

High-throughput

0.464

High

913672

DCNL4
DCN1-like protein 4

1

1

High-throughput

0.464

High

913655

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

913654

SF01
Splicing factor 1

1

9

High-throughput

0.457

High

913682

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.437

High

913683

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.437

High

94367

D6RA96
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.407

High

913648

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.265

Low

913649

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.265

Low

913670

TCP11
T-complex protein 11 homolog

1

0

High-throughput

0.265

Low

913681

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025