HitPredict

Interactor 1: CHIO (P52757)
Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3)
Gene: CHN2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	11278894, 32203420, 16628218
Identification Methods	pull down, fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 468 Hs			1 192
+	Hs
		551044 CHIN_HUMAN (17-468): 6.76e-148: 431: 73.51		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Mm
		925802 CHIO_MOUSE (189-468): 3.05e-104: 315: 97.50		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Ce
		983038 Q965N4_CAEEL (10-463): 7.33e-109: 330: 35.81		CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27
+	Hs
		893974 MYO9B_HUMAN (2-464): 2.23e-85: 288: 21.43		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900443 MYO9B_HUMAN (2-464): 2.23e-85: 288: 21.43		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436289 MYO9B_HUMAN (2-464): 2.23e-85: 288: 21.43		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		70662 MYO9A_HUMAN (23-464): 2.71e-81: 276: 19.33		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		70663 MYO9A_HUMAN (23-464): 2.71e-81: 276: 19.33		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		925395 SRGP1_HUMAN (73-468): 6.92e-68: 236: 22.81		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925599 RGAP1_HUMAN (45-462): 5.25e-69: 233: 22.38		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		200213 SRGP3_HUMAN (73-468): 1.05e-65: 230: 18.70		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925755 3BP1_HUMAN (27-468): 1.17e-66: 228: 17.23		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Dm
		776916 CDGAP_DROME (265-468): 2.52e-65: 230: 34.14		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Ce
		93900 F0IWT2_CAEEL (40-463): 9.71e-71: 246: 19.69		CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27
+	Ce
		93901 F0IWT2_CAEEL (40-463): 9.71e-71: 246: 19.69		RHO1_CAEEL (5-192): 4.91e-75: 225: 59.04
+	Hs
		892584 RGAP1_HUMAN (45-462): 5.25e-69: 233: 22.38		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		900637 SRGP1_HUMAN (73-468): 6.92e-68: 236: 22.81		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		49630 RHG10_HUMAN (292-468): 2.38e-65: 226: 36.87		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		436497 RGAP1_HUMAN (45-462): 5.25e-69: 233: 22.38		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		49631 RHG10_HUMAN (292-468): 2.38e-65: 226: 36.87		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98