Protein: PTN3
Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)

Gene: PTN3, PTPN3
Organism: Homo sapiens
Interactions: 104
UniProt ID: P26045

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0004725 - protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533831

GHR
Growth hormone receptor

1

16

Small-scale

0.770

High

683964

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

17

Small-scale

0.768

High

683969

1433B
14-3-3 protein beta/alpha

10

20

Small-scale

0.757

High

683982

1433G
14-3-3 protein gamma

9

20

High-throughput

0.755

High

683965

1433T
14-3-3 protein theta

9

20

High-throughput

0.753

High

683984

1433Z
14-3-3 protein zeta/delta

8

20

High-throughput

0.751

High

683992

1433F
14-3-3 protein eta

7

20

High-throughput

0.748

High

683983

1433E
14-3-3 protein epsilon

5

8

High-throughput

0.720

High

684016

VANG1
Vang-like protein 1

4

10

High-throughput

0.699

High

684048

KCTD3
BTB/POZ domain-containing protein KCTD3

4

11

High-throughput

0.697

High

683978

MK12
Mitogen-activated protein kinase 12

3

12

Small-scale

0.677

High

684033

WDR6
tRNA

3

7

High-throughput

0.675

High

684005

AAAT
Neutral amino acid transporter B(0)

3

5

High-throughput

0.656

High

683991

AK1C1
Aldo-keto reductase family 1 member C1

3

0

High-throughput

0.646

High

684045

SCML1
Sex comb on midleg-like protein 1

1

3

High-throughput

0.640

High

684017

SHKB1
SH3KBP1-binding protein 1

4

20

High-throughput

0.636

High

683986

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

2

4

Small-scale

0.626

High

659359

CRCM
Colorectal mutant cancer protein

2

4

High-throughput

0.621

High

684044

VANG2
Vang-like protein 2

2

10

High-throughput

0.621

High

374412

RASH
GTPase HRas

1

20

High-throughput

0.618

High

439646

INSR
Insulin receptor

1

20

Small-scale

0.618

High

683994

ZO1
Tight junction protein 1

1

20

High-throughput

0.618

High

684032

E41L5
Band 4.1-like protein 5

1

15

High-throughput

0.618

High

684041

ZO2
Tight junction protein 2

1

20

High-throughput

0.618

High

682005

RBTN1
Rhombotin-1

3

8

High-throughput

0.616

High

683980

TERA
Transitional endoplasmic reticulum ATPase

2

4

Small-scale

0.611

High

684019

TRI41
E3 ubiquitin-protein ligase TRIM41

2

3

High-throughput

0.606

High

684023

MTMR9
Myotubularin-related protein 9

2

1

High-throughput

0.606

High

683972

EPS15
Epidermal growth factor receptor substrate 15

1

14

Small-scale

0.597

High

684039

HTR5B
HEAT repeat-containing protein 5B

2

0

Small-scale

0.595

High

162087

ACOT8
Acyl-coenzyme A thioesterase 8

2

0

High-throughput

0.585

High

684031

CYBP
Calcyclin-binding protein

2

2

High-throughput

0.584

High

684046

SRRM2
Serine/arginine repetitive matrix protein 2

2

13

High-throughput

0.580

High

684028

KPCD2
Serine/threonine-protein kinase D2

2

6

High-throughput

0.576

High

410635

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

471990

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.575

High

476428

IBP1
Insulin-like growth factor-binding protein 1

2

2

High-throughput

0.574

High

684002

DIP2A
Disco-interacting protein 2 homolog A

1

1

High-throughput

0.573

High

684034

NXT2
NTF2-related export protein 2

1

1

High-throughput

0.573

High

684004

KS6A1
Ribosomal protein S6 kinase alpha-1

2

9

Small-scale

0.563

High

683981

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.554

High

683996

ILF2
Interleukin enhancer-binding factor 2

1

1

High-throughput

0.554

High

683997

ILF3
Interleukin enhancer-binding factor 3

1

6

High-throughput

0.554

High

683999

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

High-throughput

0.554

High

683971

MLH1
DNA mismatch repair protein Mlh1

2

2

High-throughput

0.553

High

684006

VWA2
von Willebrand factor A domain-containing protein 2

2

3

High-throughput

0.553

High

684030

PKHF2
Pleckstrin homology domain-containing family F member 2

2

5

High-throughput

0.553

High

684001

SCN5A
Sodium channel protein type 5 subunit alpha

1

10

Small-scale

0.552

High

415358

HSPB1
Heat shock protein beta-1

1

7

High-throughput

0.541

High

683968

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

High-throughput

0.541

High

683966

CD6
T-cell differentiation antigen CD6

1

5

High-throughput

0.536

High

683985

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.536

High

543461

VDR
Vitamin D3 receptor

1

7

Small-scale

0.534

High

684027

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.527

High

684018

ZCH10
Zinc finger CCHC domain-containing protein 10

1

7

High-throughput

0.523

High

683970

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

684009

RN111
E3 ubiquitin-protein ligase Arkadia

1

10

High-throughput

0.481

High

229956

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

350648

DLGP3
Disks large-associated protein 3

1

2

High-throughput

0.479

High

475270

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.479

High

539945

BCR
Breakpoint cluster region protein

1

14

High-throughput

0.479

High

627261

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

7

High-throughput

0.479

High

683973

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

3

High-throughput

0.479

High

683974

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.479

High

683977

KS6A3
Ribosomal protein S6 kinase alpha-3

1

5

High-throughput

0.479

High

683979

ICLN
Methylosome subunit pICln

1

6

High-throughput

0.479

High

683990

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

683993

UBE3A
Ubiquitin-protein ligase E3A

1

11

Small-scale

0.479

High

683995

KIF1A
Kinesin-like protein KIF1A

1

9

High-throughput

0.479

High

683998

DGKZ
Diacylglycerol kinase zeta

1

4

High-throughput

0.479

High

684000

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

684007

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

20

High-throughput

0.479

High

684012

MAPK5
MAP kinase-activated protein kinase 5

1

3

High-throughput

0.479

High

684013

ARL14
ADP-ribosylation factor-like protein 14

1

17

High-throughput

0.479

High

684024

KIF2C
Kinesin-like protein KIF2C

1

10

High-throughput

0.479

High

684025

LZTS2
Leucine zipper putative tumor suppressor 2

1

11

High-throughput

0.479

High

684029

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

684035

ANLN
Anillin

1

7

High-throughput

0.479

High

684038

DTL
Denticleless protein homolog

1

4

High-throughput

0.479

High

684040

S53A1
Solute carrier family 53 member 1

1

2

High-throughput

0.479

High

684042

KDIS
Kinase D-interacting substrate of 220 kDa

1

10

High-throughput

0.479

High

684010

SRCAP
Helicase SRCAP

1

6

High-throughput

0.470

High

333805

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.458

High

683975

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

683988

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.458

High

684020

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

684021

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.458

High

190194

MOT4
Monocarboxylate transporter 4

1

7

High-throughput

0.445

High

683976

GPC3
Glypican-3

1

10

High-throughput

0.445

High

684003

Q149M6
Exophilin 5

1

1

High-throughput

0.437

High

684008

MYORG
Myogenesis-regulating glycosidase

1

1

High-throughput

0.437

High

684036

WDR70
WD repeat-containing protein 70

1

5

High-throughput

0.437

High

684037

ASND1
Asparagine synthetase domain-containing protein 1

1

1

High-throughput

0.437

High

684043

ANR50
Ankyrin repeat domain-containing protein 50

1

9

High-throughput

0.437

High

684022

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.417

High

684011

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

7

High-throughput

0.407

High

684015

EXPH5
Exophilin-5

1

1

High-throughput

0.407

High

683989

TFAP4
Transcription factor AP-4

2

0

High-throughput

0.316

High

684014

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

683967

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.289

High

683987

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

684026

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

High-throughput

0.249

Low

684047

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025