HitPredict

Interactor 1: CAZA1 (P52907)
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Gene: CAPZA1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	33961781, 12690097, 22706086, 20697350
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015629 - actin cytoskeleton GO:0045296 - cadherin binding GO:0051015 - actin filament binding GO:0065003 - protein-containing complex assembly GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 639
+	Hs
		813227 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		857188 CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		813121 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		857099 CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		298962 CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40