Protein: SPAST
Spastin (EC 5.6.1.1)

Gene: SPAST
Organism: Mus musculus
Interactions: 81
UniProt ID: Q9QYY8

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000922 - spindle pole
GO:0001578 - microtubule bundle formation
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932173

PRS6B
26S proteasome regulatory subunit 6B

1

15

High-throughput

0.618

High

987303

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

18

High-throughput

0.618

High

1033506

TERA
Transitional endoplasmic reticulum ATPase

1

19

High-throughput

0.618

High

1281905

NAV3
Neuron navigator 3

1

12

High-throughput

0.618

High

1298180

ANK2
Ankyrin-2

1

2

High-throughput

0.618

High

1455915

SPAST
Spastin

1

17

High-throughput

0.618

High

64329

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

4

High-throughput

0.479

High

147431

BIN1
Myc box-dependent-interacting protein 1

1

6

High-throughput

0.479

High

204631

PURB
Transcriptional regulator protein Pur-beta

1

2

High-throughput

0.479

High

237152

STRN
Striatin

1

11

High-throughput

0.479

High

558935

RL7A
Large ribosomal subunit protein eL8

1

5

High-throughput

0.479

High

586418

H12
Histone H1.2

1

7

High-throughput

0.479

High

631797

MTAP2
Microtubule-associated protein 2

1

13

High-throughput

0.479

High

844318

TCPQ
T-complex protein 1 subunit theta

1

15

High-throughput

0.479

High

847007

H14
Histone H1.4

1

7

High-throughput

0.479

High

847036

H15
Histone H1.5

1

7

High-throughput

0.479

High

979408

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.479

High

1021420

FHL1
Four and a half LIM domains protein 1

1

1

High-throughput

0.479

High

1034658

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

5

High-throughput

0.479

High

1189226

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

1191019

Q3UZG4
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

1

2

High-throughput

0.479

High

1201218

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.479

High

1210267

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.479

High

1211111

NACAD
NAC-alpha domain-containing protein 1

1

4

High-throughput

0.479

High

1216962

GASP1
G-protein coupled receptor-associated sorting protein 1

1

2

High-throughput

0.479

High

1223127

KTN1
Kinectin

1

10

High-throughput

0.479

High

1223958

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

10

High-throughput

0.479

High

1224158

SH3G1
Endophilin-A2

1

7

High-throughput

0.479

High

1230043

CE170
Centrosomal protein of 170 kDa

1

5

High-throughput

0.479

High

1230074

LAR4B
La-related protein 4B

1

3

High-throughput

0.479

High

1244754

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

3

High-throughput

0.479

High

1281890

ASTRB
Protein Aster-B

1

1

High-throughput

0.479

High

1282803

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

8

High-throughput

0.479

High

1296582

ATLA1
Atlastin-1

1

4

High-throughput

0.479

High

1296597

Q8BH80
Vesicle-associated membrane protein, associated protein B and C

1

8

High-throughput

0.479

High

1297202

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.479

High

1297389

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

1298260

BCAS3
BCAS3 microtubule associated cell migration factor

1

3

High-throughput

0.479

High

1298564

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

9

High-throughput

0.479

High

1298773

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

8

High-throughput

0.479

High

1317301

HACD3
Very-long-chain

1

4

High-throughput

0.479

High

1341548

CDC16
Cell division cycle protein 16 homolog

1

9

High-throughput

0.479

High

1353947

VIGLN
Vigilin

1

8

High-throughput

0.479

High

1362244

SMAP1
Stromal membrane-associated protein 1

1

5

High-throughput

0.479

High

1362913

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

1362936

LRC59
Leucine-rich repeat-containing protein 59 [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]

1

4

High-throughput

0.479

High

1408951

RTN4
Reticulon-4

1

1

High-throughput

0.479

High

1408968

RRBP1
Ribosome-binding protein 1

1

14

High-throughput

0.479

High

1423854

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

8

High-throughput

0.479

High

1423972

SYRC
Arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

1424157

SPP
Signal peptide peptidase

1

2

High-throughput

0.479

High

1440896

HIP1R
Huntingtin-interacting protein 1-related protein

1

14

High-throughput

0.479

High

1440920

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

6

High-throughput

0.479

High

1455907

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

1455911

MAP1A
Microtubule-associated protein 1A

1

6

High-throughput

0.479

High

1455916

AFAD
Afadin

1

9

High-throughput

0.479

High

1455917

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

8

High-throughput

0.479

High

1455918

PDC6I
Programmed cell death 6-interacting protein

1

11

High-throughput

0.479

High

1455919

VAPA
Vesicle-associated membrane protein-associated protein A

1

8

High-throughput

0.479

High

147634

EMD
Emerin

1

0

High-throughput

0.458

High

1244312

WASC2
WASH complex subunit 2

1

0

High-throughput

0.458

High

1282874

LYRIC
Protein LYRIC

1

0

High-throughput

0.458

High

1297033

Q8BNP7
Adenomatous polyposis coli protein

1

0

High-throughput

0.458

High

1341653

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.458

High

59197

A2A9M5
Dedicator of cytokinesis 7

1

1

High-throughput

0.437

High

73066

B1AWE1
Clathrin light chain

1

4

High-throughput

0.437

High

1179618

PSD3
PH and SEC7 domain-containing protein 3

1

4

High-throughput

0.437

High

1210444

ZDBF2
DBF4-type zinc finger-containing protein 2 homolog

1

3

High-throughput

0.437

High

1274572

AMPH
Amphiphysin

1

9

High-throughput

0.437

High

1283098

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

3

High-throughput

0.437

High

1296947

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

4

High-throughput

0.437

High

1296973

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

1

High-throughput

0.437

High

1423927

CISY
Citrate synthase, mitochondrial

1

6

High-throughput

0.437

High

1424310

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

4

High-throughput

0.437

High

1440852

SV2A
Synaptic vesicle glycoprotein 2A

1

5

High-throughput

0.437

High

1455914

PCLO
Protein piccolo

1

6

High-throughput

0.437

High

941877

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.249

Low

1071131

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

0

High-throughput

0.249

Low

1220133

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

1423938

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025