Interactor 1: NKX25 (P52952)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: NKX2-5

Interactor 2: NKX24 (Q9H2Z4)
Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D)
Gene: NKX2-4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.646

The method score is based on:

Property Details
Experiments 35140242
Identification Methods affinity chromatography technology
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Homeodomain~Homeodomain
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
and 1 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 324
Hs

1 354
+ Hs
+ Ce
+ Ce
+ Hs
+ Ce
+ Hs
+ Hs
+ Dm
+ Hs
+ Ce
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Ce
+ Mm

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Last updated: 15 Jul 2024