HitPredict

Interactor 1: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Interactor 2: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	19176521
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 1972
+	Mm
		541465 PPP5_MOUSE (1-499): 0: 571: 97.80		MAP1B_MOUSE (66-1605): 2.35e-49: 196: 8.75
+	Mm
		1141242 PPP5_MOUSE (1-499): 0: 571: 97.80		MAP1A_MOUSE (6-1484): 9.23e-33: 142: 12.26
+	Hs
		807671 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41
+	Hs
		905838 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		ANK2_HUMAN (3-1685): 1.72e-50: 200: 9.45
+	Dm
		54887 Q9VH81_DROME (4-494): 8.41e-179: 513: 59.60		A1ZA72_DROME (68-1020): 1.77e-25: 118: 11.26
+	Hs
		930846 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33
+	Dm
		1214030 Q9VH81_DROME (4-494): 8.41e-179: 513: 59.60		LUBEL_DROME (413-1341): 4.25e-11: 70.9: 12.91
+	Dm
		1248657 Q9VH81_DROME (4-494): 8.41e-179: 513: 59.60		SPEN_DROME (7-1724): 1.84e-10: 68.7: 9.41
+	Dm
		54320 Q8T0U6_DROME (144-479): 8.62e-163: 470: 34.22		A1Z9J3_DROME (566-1248): 2.07e-18: 95.2: 13.41
+	Hs
		905894 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33
+	Hs
		891014 PP4C_HUMAN (187-488): 7.07e-164: 467: 39.61		SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78
+	Ce
		821920 GLC7B_CAEEL (196-485): 1.11e-154: 445: 38.49		MEL28_CAEEL (462-1118): 1.6e-20: 101: 15.40
+	Ce
		1090117 GLC7A_CAEEL (204-484): 5.64e-153: 440: 38.30		MEL28_CAEEL (462-1118): 1.6e-20: 101: 15.40
+	Hs
		738130 PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88		SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78
+	Dm
		115296 PP1B_DROME (196-484): 2.83e-150: 434: 37.24		M9PEP8_DROME (213-1163): 5.89e-10: 67: 13.15
+	Dm
		113980 PP1B_DROME (196-484): 2.83e-150: 434: 37.24		M9PB30_DROME (1064-1755): 2.27e-09: 65.1: 8.65