HitPredict

Interactor 1: CUL3 (P53202)
Cullin-3 (Cullin-B)
Gene: CUL3

Interactor 2: RUB1 (Q03919)
NEDD8-like protein RUB1 (Related to ubiquitin protein 1) (Ubiquitin-like protein RUB1)
Gene: RUB1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	14519104, 37968396
Identification Methods	comigration in sds page, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 744 Sc			1 77
+	Hs
		923984 CUL4A_HUMAN (4-744): 0: 751: 22.38		RS27A_HUMAN (1-76): 3.48e-37: 123: 52.63
+	Hs
		924296 CUL4A_HUMAN (4-744): 0: 751: 22.38		RL40_HUMAN (1-76): 2.25e-34: 115: 52.63
+	Hs
		1043010 CUL4A_HUMAN (4-744): 0: 751: 22.38		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21
+	Hs
		923983 CUL3_HUMAN (2-744): 0: 741: 24.30		RS27A_HUMAN (1-76): 3.48e-37: 123: 52.63
+	Hs
		923985 CUL4B_HUMAN (3-744): 0: 740: 22.62		RS27A_HUMAN (1-76): 3.48e-37: 123: 52.63
+	At
		1352191 CUL3A_ARATH (2-744): 0: 765: 23.78		RUB1_ARATH (3-76): 5.75e-27: 97.1: 58.11
+	Hs
		1041658 CUL3_HUMAN (2-744): 0: 741: 24.30		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21
+	Hs
		1043371 CUL4B_HUMAN (3-744): 0: 740: 22.62		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21
+	Hs
		475024 CUL4B_HUMAN (3-744): 0: 740: 22.62		UBB_HUMAN (1-76): 2.37e-31: 110: 52.63
+	At
		1321116 CUL3B_ARATH (2-744): 0: 750: 23.65		RUB1_ARATH (3-76): 5.75e-27: 97.1: 58.11
+	Dm
		1213846 Q8IP45_DROME (10-744): 0: 715: 24.07		NEDD8_DROME (1-77): 2.58e-33: 111: 59.74
+	Hs
		1041004 CUL1_HUMAN (8-744): 0: 710: 19.42		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21
+	Ce
		1088883 CUL3_CAEEL (5-744): 0: 667: 23.58		NEDD8_CAEEL (1-76): 1.03e-32: 109: 60.53
+	Hs
		1041337 CUL2_HUMAN (21-744): 0: 654: 19.37		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21
+	At
		1277343 CUL1_ARATH (20-744): 0: 669: 20.08		RUB1_ARATH (3-76): 5.75e-27: 97.1: 58.11
+	At
		1247030 CUL1_ARATH (20-744): 0: 669: 20.08		RUB2_ARATH (3-76): 6.74e-26: 94.4: 58.11
+	Dm
		1097203 CUL1_DROME (22-744): 0: 650: 18.73		NEDD8_DROME (1-77): 2.58e-33: 111: 59.74
+	Sp
		142907 CUL1_SCHPO (5-744): 0: 633: 20.13		UBL1_SCHPO (1-77): 1.91e-33: 111: 59.74
+	Sp
		145590 CUL3_SCHPO (1-744): 0: 610: 24.16		UBL1_SCHPO (1-77): 1.91e-33: 111: 59.74
+	Hs
		1079566 CUL5_HUMAN (22-744): 0: 563: 16.13		NEDD8_HUMAN (1-76): 1.61e-34: 113: 59.21