HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	28514442, 33961781, 30267576, 32877691, 35733260, 19546225
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 540
+	Hs
		861899 PLK1_HUMAN (1-603): 0: 617: 100.00		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Mm
		101422 KS6A3_MOUSE (1-326): 1.59e-103: 331: 25.44		F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24
+	Hs
		1057021 KS6A6_HUMAN (48-372): 3.93e-100: 322: 25.52		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		160565 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		160725 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58