HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: PP6R1 (Q9UPN7)
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)
Gene: PPP6R1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25659891, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 881
+	Hs
		257169 PLK1_HUMAN (1-603): 0: 617: 100.00		PP6R2_HUMAN (1-880): 0: 793: 40.08
+	Hs
		861783 PLK1_HUMAN (1-603): 0: 617: 100.00		PP6R3_HUMAN (1-876): 0: 766: 43.85
+	Hs
		1354260 KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66		PP6R1_HUMAN (1-881): 0: 828: 100.00
+	Hs
		1126056 KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66		PP6R3_HUMAN (1-876): 0: 766: 43.85
+	Hs
		257178 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		PP6R2_HUMAN (1-880): 0: 793: 40.08
+	Hs
		257167 KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44		PP6R2_HUMAN (1-880): 0: 793: 40.08
+	Ce
		70235 PLK1_CAEEL (22-599): 0: 536: 50.58		PPH6R_CAEEL (1-795): 2.34e-136: 427: 17.40
+	Hs
		160281 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		PP6R2_HUMAN (1-880): 0: 793: 40.08
+	Hs
		160607 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		PP6R3_HUMAN (1-876): 0: 766: 43.85
+	Ce
		70232 G5EDL3_CAEEL (56-293): 9.33e-42: 155: 35.42		PPH6R_CAEEL (1-795): 2.34e-136: 427: 17.40
+	Hs
		160785 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		UBP42_HUMAN (468-864): 1.5e-31: 135: 12.11