Interactor 1: SUCA (P53597)
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
Gene: SUCLG1

Interactor 2: SUCB1 (Q9P2R7)
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
Gene: SUCLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-grasp_2~CoA_binding, CoA_binding~Ligase_CoA, ATP-grasp_2~Ligase_CoA, Ligase_CoA~Ligase_CoA
Common GO terms GO:0004775 - succinate-CoA ligase (ADP-forming) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006099 - tricarboxylic acid cycle
GO:0009361 - succinate-CoA ligase complex (ADP-forming)
and 1 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 346
Hs

1 463
+ Ss
+ Hs
+ Sc
+ Ec
+ Cj
+ Hs

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Last updated: 15 Jul 2024