HitPredict

Interactor 1: COPA (P53621)
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
Gene: COPA

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29991511
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1224 Hs			1 446
+	Hs
		863397 COPA_HUMAN (1-1224): 0: 1334: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Sc
		744660 COPA_YEAST (1-1218): 0: 967: 42.71		TAF5_YEAST (250-445): 1.54e-31: 129: 16.75
+	Sc
		863617 COPA_YEAST (1-1218): 0: 967: 42.71		COPA_YEAST (299-445): 1.42e-23: 106: 17.01
+	Hs
		1202778 WDR5B_HUMAN (443-701): 1.92e-29: 122: 12.04		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Dm
		1358845 WDS_DROME (407-617): 3.01e-43: 163: 11.01		WDS_DROME (248-445): 1.19e-46: 166: 21.21
+	Hs
		903349 WDR5B_HUMAN (443-701): 1.92e-29: 122: 12.04		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		792949 LIS1_HUMAN (359-573): 1.07e-16: 85.8: 13.10		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		725410 COPB2_HUMAN (481-644): 1.35e-13: 77.8: 10.53		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Mm
		925836 LIS1_MOUSE (359-573): 9.74e-17: 86.2: 13.10		LIS1_MOUSE (243-445): 5.09e-42: 155: 17.00
+	Hs
		792935 LIS1_HUMAN (359-573): 1.07e-16: 85.8: 13.10		LIS1_HUMAN (243-445): 6.45e-42: 155: 17.00
+	Hs
		903077 WDR5_HUMAN (520-631): 6.51e-11: 67.4: 10.35		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Sc
		744636 COPB2_YEAST (2-272): 3.07e-17: 89.7: 12.28		TAF5_YEAST (250-445): 1.54e-31: 129: 16.75
+	Sc
		784397 COPB2_YEAST (2-272): 3.07e-17: 89.7: 12.28		COPA_YEAST (299-445): 1.42e-23: 106: 17.01
+	Hs
		793026 LIS1_HUMAN (359-573): 1.07e-16: 85.8: 13.10		KTNB1_HUMAN (55-289): 7.58e-23: 103: 15.98
+	Ce
		954090 LIS1_CAEEL (238-369): 1.84e-17: 88.2: 20.59		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33
+	Ce
		953972 COPB2_CAEEL (2-270): 3.7e-12: 73.1: 11.66		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33
+	Hs
		903171 WDR5_HUMAN (520-631): 6.51e-11: 67.4: 10.35		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		903313 WDR5_HUMAN (520-631): 6.51e-11: 67.4: 10.35		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23