HitPredict

Interactor 1: ICLN (P54105)
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
Gene: CLNS1A

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Voldacs
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 237 Hs			1 139
+	Hs
		867492 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		867409 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		867411 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		867458 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		LSM10_HUMAN (3-104): 9.38e-28: 100: 24.51
+	Hs
		867405 ICLN_HUMAN (1-237): 2.09e-113: 326: 100.00		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Ce
		107955 G5EFZ5_CAEEL (12-200): 1.7e-57: 183: 33.16		SMD3_CAEEL (2-124): 3.32e-33: 115: 30.23
+	Dm
		55530 ICLN_DROME (12-193): 1.41e-52: 171: 27.36		Q9VTW6_DROME (1-89): 1.77e-36: 122: 30.00
+	Ce
		107954 G5EFZ5_CAEEL (12-200): 1.7e-57: 183: 33.16		SMD1_CAEEL (1-88): 8.41e-30: 106: 25.84
+	Ce
		107977 G5EG22_CAEEL (12-200): 2.28e-53: 173: 29.58		SMD3_CAEEL (2-124): 3.32e-33: 115: 30.23
+	Ce
		107976 G5EG22_CAEEL (12-200): 2.28e-53: 173: 29.58		SMD1_CAEEL (1-88): 8.41e-30: 106: 25.84