HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	16713569, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 788
+	Hs
		868656 ATX1_HUMAN (1-815): 0: 1349: 100.00		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Mm
		868951 ATX1_MOUSE (1-815): 0: 1271: 86.89		SC31A_MOUSE (137-654): 7.47e-27: 119: 14.23
+	Mm
		101431 ATX1_MOUSE (1-815): 0: 1271: 86.89		F8VPR5_MOUSE (147-583): 8.96e-10: 64.8: 11.19
+	Hs
		159858 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08