HitPredict

Interactor 1: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Interactor 2: ZHX1 (Q9UKY1)
Zinc fingers and homeoboxes protein 1
Gene: ZHX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	12659632, 16713569, 32814053
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 815 Hs			1 873
+	Hs
		868740 ATX1_HUMAN (1-815): 0: 1349: 100.00		ZHX3_HUMAN (1-873): 0: 589: 32.70
+	Hs
		868836 ATX1_HUMAN (1-815): 0: 1349: 100.00		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		868805 ATX1_HUMAN (1-815): 0: 1349: 100.00		LHX6_HUMAN (452-558): 2.69e-14: 77.4: 17.76
+	Hs
		641350 ATX1_HUMAN (1-815): 0: 1349: 100.00		PAX6_HUMAN (628-784): 3.52e-12: 71.3: 18.29
+	Hs
		868776 ATX1_HUMAN (1-815): 0: 1349: 100.00		VSX1_HUMAN (370-524): 3.68e-12: 70.9: 16.30
+	Hs
		473577 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		LHX6_HUMAN (452-558): 2.69e-14: 77.4: 17.76
+	Hs
		473472 ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15		PAX6_HUMAN (628-784): 3.52e-12: 71.3: 18.29