Protein: FCF1
rRNA-processing protein FCF1 homolog

Gene: FCF1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9Y324

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1411918

UTP23
rRNA-processing protein UTP23 homolog

1

2

Small-scale

0.647

High

609848

LEG3
Galectin-3

2

2

High-throughput

0.628

High

945882

EPIPL
Epiplakin

2

2

High-throughput

0.628

High

1118010

PKP1
Plakophilin-1

2

1

High-throughput

0.628

High

1491045

PKP3
Plakophilin-3

2

1

High-throughput

0.628

High

586963

RS2
Small ribosomal subunit protein uS5

2

2

High-throughput

0.611

High

1409879

RBM4B
RNA-binding protein 4B

2

1

High-throughput

0.611

High

384752

CRYAB
Alpha-crystallin B chain

2

0

High-throughput

0.602

High

615251

IL1RA
Interleukin-1 receptor antagonist protein

2

0

High-throughput

0.602

High

636190

ENDOU
Uridylate-specific endoribonuclease

2

0

High-throughput

0.602

High

729632

CASPE
Caspase-14

2

0

High-throughput

0.602

High

1461878

ASC
Apoptosis-associated speck-like protein containing a CARD

2

0

High-throughput

0.602

High

1454410

BCCIP
BRCA2 and CDKN1A-interacting protein

2

0

High-throughput

0.580

High

210802

KLK10
Kallikrein-10

2

1

High-throughput

0.574

High

248802

PEPL
Periplakin

2

3

High-throughput

0.574

High

424569

PAI2
Plasminogen activator inhibitor 2

2

3

High-throughput

0.574

High

787726

SPB5
Serpin B5

2

3

High-throughput

0.574

High

868799

LEG7
Galectin-7

2

2

High-throughput

0.574

High

892149

KLK7
Kallikrein-7

2

1

High-throughput

0.574

High

895475

SPB8
Serpin B8

2

3

High-throughput

0.574

High

1120997

TRI29
Tripartite motif-containing protein 29

2

3

High-throughput

0.574

High

1309636

SPA12
Serpin A12

2

3

High-throughput

0.574

High

1369027

EVPL
Envoplakin

2

4

High-throughput

0.574

High

1453606

CALL5
Calmodulin-like protein 5

2

1

High-throughput

0.574

High

191868

MAGB2
Melanoma-associated antigen B2

2

1

High-throughput

0.549

High

287201

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

5

High-throughput

0.536

High

290801

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

522024

H14
Histone H1.4

1

6

High-throughput

0.536

High

686535

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

785545

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

842603

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

905319

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.536

High

976042

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.536

High

977113

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.536

High

985083

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

985961

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

1057969

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.536

High

1061219

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.536

High

1361802

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.536

High

1460505

SPB13
Serpin B13

1

3

High-throughput

0.536

High

288872

LYPA1
Acyl-protein thioesterase 1

1

0

High-throughput

0.513

High

711749

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

818778

CAPG
Macrophage-capping protein

1

0

High-throughput

0.513

High

984595

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

1137202

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.513

High

551640

NFH
Neurofilament heavy polypeptide

1

2

High-throughput

0.489

High

1127539

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1192174

LEGL
Galectin-related protein

1

2

High-throughput

0.489

High

1277807

MYH14
Myosin-14

1

2

High-throughput

0.489

High

96797

E9PAV9
G patch domain-containing protein 4

1

3

High-throughput

0.479

High

406823

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

773094

MYH9
Myosin-9

1

2

High-throughput

0.479

High

879645

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

1027867

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

High-throughput

0.479

High

1125267

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

3

High-throughput

0.479

High

1138187

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1454369

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

590093

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

937982

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

1161770

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1393850

DDRGK
DDRGK domain-containing protein 1

1

0

Small-scale

0.458

High

1459398

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

423499

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

288824

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.445

High

809929

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.445

High

861027

RS10
Small ribosomal subunit protein eS10

1

2

High-throughput

0.445

High

960038

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.445

High

969529

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.445

High

1006809

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.445

High

1099314

SRSF5
Serine/arginine-rich splicing factor 5

1

4

High-throughput

0.445

High

1212392

GPTC4
G patch domain-containing protein 4

1

3

High-throughput

0.445

High

1335092

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.445

High

1411567

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.445

High

1437423

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1453904

H2AW
Core histone macro-H2A.2

1

2

High-throughput

0.445

High

1461416

ZN346
Zinc finger protein 346

1

2

High-throughput

0.445

High

1364123

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.437

High

1119383

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1140057

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.426

High

1239985

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1244343

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.426

High

1314075

YAF2
YY1-associated factor 2

1

0

High-throughput

0.426

High

1241067

L2GL2
LLGL scribble cell polarity complex component 2

1

1

High-throughput

0.407

High

126266

ST2B1
Sulfotransferase 2B1

2

0

High-throughput

0.328

High

457937

INVO
Involucrin

2

0

High-throughput

0.328

High

582645

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.328

High

635650

FILA
Filaggrin

2

0

High-throughput

0.328

High

839646

HUTH
Histidine ammonia-lyase

2

0

High-throughput

0.328

High

870661

MAOX
NADP-dependent malic enzyme

2

0

High-throughput

0.328

High

956626

RAB5B
Ras-related protein Rab-5B

2

0

High-throughput

0.328

High

1200358

APRV1
Retroviral-like aspartic protease 1

2

0

High-throughput

0.328

High

1213863

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.328

High

1218707

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.328

High

1231968

DMKN
Dermokine

2

0

High-throughput

0.328

High

1248758

SBSN
Suprabasin

2

0

High-throughput

0.328

High

1257005

FBX50
F-box only protein 50

2

0

High-throughput

0.328

High

1338083

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

0

High-throughput

0.328

High

1358605

POF1B
Protein POF1B

2

0

High-throughput

0.328

High

1410011

TREX2
Three prime repair exonuclease 2

2

0

High-throughput

0.328

High

1208353

SPDYC
Speedy protein C

2

0

High-throughput

0.316

High

276645

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

423719

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

692846

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1118267

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.279

Low

1154361

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1431056

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

567115

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.269

Low

401737

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

379413

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025