HitPredict

Interactor 1: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	32296183, 33277362, unassigned1304, 17098253
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, nuclear magnetic resonance, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~UBA, UBA~ubiquitin, ubiquitin~ubiquitin, UBA~XPC-binding
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 363 Hs			1 624
+	Hs
		872229 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		872317 RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		872222 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Mm
		1307911 UBQL4_MOUSE (3-312): 2.63e-48: 173: 16.36		UBQL2_MOUSE (1-624): 1.66e-145: 437: 84.01
+	Mm
		1246842 UBQL1_MOUSE (2-312): 1.18e-47: 171: 16.40		UBQL2_MOUSE (1-624): 1.66e-145: 437: 84.01
+	Dm
		1362833 Q9VCD5_DROME (3-362): 3.96e-58: 191: 27.90		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		1345051 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		872275 RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		872137 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		872136 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Dm
		1362834 Q9VCD5_DROME (3-362): 3.96e-58: 191: 27.90		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		803807 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Sc
		697098 RAD23_YEAST (3-361): 1e-75: 240: 28.57		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19
+	Sp
		251965 RHP23_SCHPO (3-363): 2.02e-78: 247: 33.25		DSK2_SCHPO (33-240): 1.27e-27: 116: 23.26
+	Dm
		547941 Q9V3W9_DROME (3-362): 9.91e-87: 269: 38.43		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33
+	Dm
		574854 Q9VCD5_DROME (3-362): 3.96e-58: 191: 27.90		RL40_DROME (33-112): 3.08e-31: 120: 30.86
+	Hs
		924435 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		1174926 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		TMUB2_HUMAN (6-143): 8.33e-26: 110: 25.00
+	Hs
		924216 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Dm
		547946 Q9VCD5_DROME (3-362): 3.96e-58: 191: 27.90		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33