HitPredict

Interactor 1: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0032956 - regulation of actin cytoskeleton organization GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1037 Hs			1 191
+	Hs
		872423 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		872424 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		545285 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436223 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		872418 EPHA5_HUMAN (1-1037): 0: 1374: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564541 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		1072595 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925297 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		665387 EPHA3_HUMAN (51-1037): 0: 1232: 66.53		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		951011 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900497 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545394 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436317 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892388 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		872667 EPHA4_HUMAN (33-1035): 0: 1223: 62.04		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		1072530 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		892660 EPHA6_HUMAN (28-1034): 0: 1198: 57.03		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564420 EPHA2_HUMAN (58-1037): 0: 1105: 50.86		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		545218 EPHA2_HUMAN (58-1037): 0: 1105: 50.86		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436169 EPHA2_HUMAN (58-1037): 0: 1105: 50.86		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41