HitPredict

Interactor 1: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Interactor 2: LRIQ1 (Q96JM4)
Leucine-rich repeat and IQ domain-containing protein 1
Gene: LRRIQ1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 987 Hs			1 1722
+	Hs
		665646 EPHB2_HUMAN (17-974): 0: 1118: 55.64		LRIQ1_HUMAN (1-1722): 0: 1015: 100.00
+	Hs
		1072575 EPHA7_HUMAN (3-981): 0: 1100: 48.64		LRIQ1_HUMAN (1-1722): 0: 1015: 100.00
+	Hs
		665419 EPHA3_HUMAN (13-975): 0: 1080: 48.35		LRIQ1_HUMAN (1-1722): 0: 1015: 100.00
+	Hs
		665312 EPHA2_HUMAN (15-974): 0: 1016: 44.82		LRIQ1_HUMAN (1-1722): 0: 1015: 100.00
+	Hs
		872546 EPHB4_HUMAN (1-987): 0: 1122: 100.00		LRC33_HUMAN (812-1118): 6.58e-33: 140: 16.29
+	Hs
		665407 EPHA3_HUMAN (13-975): 0: 1080: 48.35		LRC49_HUMAN (943-1152): 3.03e-15: 83.3: 25.00
+	Hs
		665495 EPHA8_HUMAN (17-978): 0: 1019: 44.89		LRC49_HUMAN (943-1152): 3.03e-15: 83.3: 25.00
+	At
		1114696 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		ERECT_ARATH (834-1396): 4.55e-89: 315: 15.35
+	At
		99017 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		RGI4_ARATH (820-1330): 3.28e-57: 219: 14.10
+	At
		1278209 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		FLS2_ARATH (1002-1331): 2.68e-46: 185: 14.09
+	At
		186969 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		BRI1_ARATH (704-1079): 3.09e-36: 152: 16.12
+	At
		84597 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		RGI3_ARATH (1049-1533): 1.31e-35: 150: 14.72
+	At
		85361 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		ERL1_ARATH (1082-1401): 2.13e-32: 139: 10.03
+	At
		83975 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		Y1743_ARATH (777-1211): 2.27e-31: 136: 12.88
+	At
		1167616 NIK2_ARATH (348-916): 3.28e-149: 459: 15.64		ERL2_ARATH (811-1061): 1.18e-28: 127: 14.89
+	At
		1167621 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		ERL2_ARATH (811-1061): 1.18e-28: 127: 14.89
+	At
		84744 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		Y4361_ARATH (1107-1336): 7.9e-21: 102: 11.48
+	Hs
		537756 INSRR_HUMAN (293-911): 3.59e-145: 467: 25.08		LRC49_HUMAN (943-1152): 3.03e-15: 83.3: 25.00
+	At
		287464 BAK1_ARATH (333-901): 2.47e-148: 455: 16.78		SKM1_ARATH (1114-1367): 1.29e-18: 94.9: 10.62
+	At
		1247619 NIK2_ARATH (348-916): 3.28e-149: 459: 15.64		PXC2_ARATH (1196-1410): 3.18e-09: 64.1: 9.82