HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 258
+	Hs
		436317 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		436223 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		1072530 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		892388 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		951011 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925297 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		872418 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		872424 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		900497 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545394 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		872423 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		545285 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		665387 EPHA3_HUMAN (26-986): 0: 1182: 63.01		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		872419 EPHA5_HUMAN (2-986): 0: 1201: 63.67		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564541 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1072595 EPHA7_HUMAN (5-986): 0: 1212: 62.37		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		892660 EPHA6_HUMAN (5-986): 0: 1140: 57.75		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		665466 EPHA8_HUMAN (30-981): 0: 1107: 57.11		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		436169 EPHA2_HUMAN (27-986): 0: 1059: 50.36		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		545218 EPHA2_HUMAN (27-986): 0: 1059: 50.36		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52