HitPredict

Interactor 1: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Interactor 2: VAMP3 (Q15836)
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
Gene: VAMP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	30833792, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0061025 - membrane fusion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 295 Hs			1 100
+	Hs
		261646 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		261720 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		850546 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Hs
		873528 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		873576 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Mm
		659546 SNAB_MOUSE (1-292): 6.03e-113: 329: 84.25		VAMP2_MOUSE (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		263203 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Dm
		577215 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		SYB_DROME (6-97): 5.15e-29: 103: 59.78
+	Hs
		306778 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Hs
		306867 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Dm
		1095560 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		Q7JYX5_DROME (6-94): 1.48e-27: 101: 23.60
+	Zm
		31296 A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80		A0A1D6KH00_MAIZE (8-97): 3.63e-32: 119: 31.11
+	Sc
		696608 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		NYV1_YEAST (2-98): 6.05e-23: 90.4: 23.47
+	Sc
		605825 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		SEC22_YEAST (1-97): 1.07e-21: 86.2: 18.56
+	Sc
		678143 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		SNC1_YEAST (6-81): 2.11e-21: 83.1: 32.90
+	Hs
		261710 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		850592 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Hs
		926249 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		263338 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		306855 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57