HitPredict

Interactor 1: PSMD4 (P55035)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (54 kDa subunit of mu particle) (Multiubiquitin chain-binding protein) (p54)
Gene: Rpn10

Interactor 2: Q9VWD9 (Q9VWD9)
LD38919p (Ubiquilin, isoform A) (Ubiquilin, isoform B)
Gene: Ubqn

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	22215586, 22364263, 21973017, 19079254
Identification Methods	pull down, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 396 Dm			1 547
+	Hs
		874198 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL1_HUMAN (7-539): 6.9e-125: 380: 44.83
+	Hs
		874195 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL2_HUMAN (5-539): 8.79e-116: 358: 39.43
+	Hs
		874185 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL4_HUMAN (9-539): 1.18e-108: 338: 41.67
+	Xl
		1118797 Q4V845_XENLA (1-384): 1.43e-172: 488: 53.25		Q9PVN8_XENLA (3-539): 2.47e-102: 321: 41.37
+	Hs
		803454 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		BAG6_HUMAN (2-497): 2.65e-57: 209: 14.15
+	Xl
		1118798 Q4V845_XENLA (1-384): 1.43e-172: 488: 53.25		BAG6A_XENLA (4-497): 3.34e-54: 199: 13.08
+	Rn
		1117345 Q9ESH1_RAT (1-384): 2.79e-175: 495: 53.51		RD23B_RAT (9-395): 2.38e-44: 164: 10.75
+	Hs
		872242 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RD23B_HUMAN (9-395): 4.27e-44: 163: 11.14
+	Hs
		874144 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		DDI1_HUMAN (20-246): 1.31e-38: 147: 20.34
+	Hs
		874117 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		DDI2_HUMAN (20-246): 1.74e-33: 133: 19.92
+	Hs
		872125 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RD23A_HUMAN (8-395): 3.15e-33: 132: 14.36
+	Dm
		874035 PSMD4_DROME (1-396): 1.39e-168: 478: 100.00		Q9V3W9_DROME (9-356): 2.08e-37: 144: 11.52
+	Dm
		874047 PSMD4_DROME (1-396): 1.39e-168: 478: 100.00		Q9VXF9_DROME (9-239): 1.31e-32: 131: 21.07
+	At
		874019 PSMD4_ARATH (1-396): 6.77e-141: 408: 40.44		RD23B_ARATH (9-395): 4.91e-55: 191: 13.71
+	At
		874018 PSMD4_ARATH (1-396): 6.77e-141: 408: 40.44		RD23A_ARATH (9-395): 3.61e-54: 189: 14.72
+	At
		874016 PSMD4_ARATH (1-396): 6.77e-141: 408: 40.44		RD23D_ARATH (9-395): 2.53e-53: 187: 15.01
+	At
		874017 PSMD4_ARATH (1-396): 6.77e-141: 408: 40.44		RD23C_ARATH (9-395): 1.06e-51: 184: 14.63
+	Hs
		874069 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RL40_HUMAN (9-91): 3.32e-24: 99: 35.71
+	Hs
		874068 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RS27A_HUMAN (9-79): 8.33e-12: 65.3: 37.50
+	Dm
		547908 PSMD4_DROME (1-396): 1.39e-168: 478: 100.00		RS27A_DROME (9-79): 8.33e-12: 65.3: 37.50