HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 27114451
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1083
+	Hs
		808062 PSMD4_HUMAN (1-364): 0: 530: 100.00		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		874079 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		125283 PSMD4_HUMAN (1-364): 0: 530: 100.00		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		874179 PSMD4_HUMAN (1-364): 0: 530: 100.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		874156 PSMD4_HUMAN (1-364): 0: 530: 100.00		NED4L_HUMAN (572-1081): 2.17e-174: 538: 25.33
+	Sc
		756928 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RSP5_YEAST (489-1081): 1.73e-170: 523: 21.30
+	Hs
		874130 PSMD4_HUMAN (1-364): 0: 530: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		756984 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		HUL5_YEAST (662-1083): 8.08e-75: 268: 39.07
+	Sc
		757016 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12