HitPredict

Interactor 1: GEM (P55040)
GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)
Gene: GEM

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 296 Hs			1 247
+	Hs
		874260 GEM_HUMAN (1-296): 6.84e-96: 286: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		271818 REM1_HUMAN (1-296): 7.83e-83: 253: 47.35		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		909599 RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		271820 REM1_HUMAN (1-296): 7.83e-83: 253: 47.35		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		904422 RB11A_HUMAN (66-293): 3.37e-80: 243: 26.09		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		904607 RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		683223 GEM_HUMAN (1-296): 6.84e-96: 286: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		874262 GEM_HUMAN (1-296): 6.84e-96: 286: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Mm
		874362 GEM_MOUSE (1-296): 1.16e-93: 280: 95.61		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		646749 GEM_HUMAN (1-296): 6.84e-96: 286: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Mm
		292073 RAD_MOUSE (14-296): 2.52e-90: 272: 56.54		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		874364 RAD_HUMAN (9-296): 4.96e-86: 261: 55.86		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Mm
		193598 REM1_MOUSE (1-296): 3.12e-84: 256: 46.36		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		271819 REM1_HUMAN (1-296): 7.83e-83: 253: 47.35		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		271817 REM1_HUMAN (1-296): 7.83e-83: 253: 47.35		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		927083 RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Mm
		926856 REM2_MOUSE (76-296): 2.24e-70: 223: 51.09		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		919617 RAP1A_HUMAN (76-239): 4.07e-22: 92.8: 35.93		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59