HitPredict

Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	18775313, 22466964, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 806 Hs			1 745
+	Hs
		874905 TERA_HUMAN (1-806): 0: 749: 100.00		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		874908 TERA_HUMAN (1-806): 0: 749: 100.00		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		874909 TERA_HUMAN (1-806): 0: 749: 100.00		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		874907 TERA_HUMAN (1-806): 0: 749: 100.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Dm
		1097193 TERA_DROME (5-806): 0: 734: 82.96		CUL1_DROME (6-745): 0: 726: 33.25
+	Hs
		875192 TERA_HUMAN (1-806): 0: 749: 100.00		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Sc
		636771 CDC48_YEAST (2-806): 0: 720: 67.75		CDC53_YEAST (5-745): 0: 622: 25.94
+	Hs
		1040745 PEX6_HUMAN (65-764): 1.02e-129: 413: 27.50		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042056 AFG2A_HUMAN (85-429): 1.24e-69: 248: 33.14		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042444 AFG2B_HUMAN (457-801): 2.18e-65: 234: 30.75		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		218008 PEX1_HUMAN (6-424): 6.61e-62: 229: 27.99		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		177499 NVL_HUMAN (426-801): 5.22e-61: 223: 25.77		CUL3_HUMAN (1-745): 0: 768: 26.38