HitPredict

Interactor 1: PAR2 (P55085)
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Gene: F2RL1

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28298427
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 397 Hs			1 236
+	Hs
		849732 CCR9_HUMAN (72-396): 3.58e-80: 252: 24.48		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		783911 CCR9_HUMAN (72-396): 3.58e-80: 252: 24.48		TSN7_HUMAN (1-234): 7.1e-56: 180: 22.31
+	Hs
		428997 ADRB2_HUMAN (42-383): 5.38e-71: 230: 14.79		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		722930 ADA1A_HUMAN (54-384): 8.6e-67: 221: 15.92		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		783813 CCR2_HUMAN (47-362): 4.05e-68: 221: 24.38		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		876180 PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00		TSN17_HUMAN (8-235): 5.76e-55: 178: 21.37
+	Hs
		428955 ADRB2_HUMAN (42-383): 5.38e-71: 230: 14.79		TSN7_HUMAN (1-234): 7.1e-56: 180: 22.31
+	Hs
		446019 PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00		CD63_HUMAN (1-232): 2.98e-52: 170: 22.95
+	Hs
		428918 ADRB2_HUMAN (42-383): 5.38e-71: 230: 14.79		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		783809 CCR2_HUMAN (47-362): 4.05e-68: 221: 24.38		TSN7_HUMAN (1-234): 7.1e-56: 180: 22.31
+	Hs
		326045 CCR6_HUMAN (72-394): 3.15e-79: 250: 23.57		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237794 CCR6_HUMAN (72-394): 3.15e-79: 250: 23.57		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88
+	Hs
		326064 GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237805 GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88
+	Hs
		237799 PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88
+	Hs
		208446 OX2R_HUMAN (23-392): 8.34e-73: 236: 18.93		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326031 NK3R_HUMAN (32-395): 2.45e-72: 235: 17.60		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		502891 AGTR1_HUMAN (48-391): 4.06e-71: 228: 24.29		CD37_HUMAN (2-232): 3.4e-44: 151: 20.00
+	Hs
		326034 AGTR1_HUMAN (48-391): 4.06e-71: 228: 24.29		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237791 OPRX_HUMAN (40-376): 2.58e-68: 222: 23.75		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88