Protein: IRF7
Interferon regulatory factor 7 (IRF-7)

Gene: IRF7
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q92985

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002376 - immune system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129169

IRF3
Interferon regulatory factor 3

5

17

Small-scale

0.924

High

1371130

IRF7
Interferon regulatory factor 7

5

17

Small-scale

0.909

High

838152

STAT1
Signal transducer and activator of transcription 1-alpha/beta

4

20

Small-scale

0.881

High

913154

STAT2
Signal transducer and activator of transcription 2

4

20

Small-scale

0.881

High

533962

IRF1
Interferon regulatory factor 1

3

15

Small-scale

0.839

High

1067577

EP300
Histone acetyltransferase p300

2

17

Small-scale

0.768

High

1028136

IRF9
Interferon regulatory factor 9

2

16

Small-scale

0.754

High

1110878

IRF5
Interferon regulatory factor 5

2

15

Small-scale

0.754

High

1371151

TRAF6
TNF receptor-associated factor 6

8

20

Small-scale

0.750

High

378340

IFN14
Interferon alpha-14

5

20

Small-scale

0.702

High

378379

IFNB
Interferon beta

5

20

Small-scale

0.702

High

1371137

MYD88
Myeloid differentiation primary response protein MyD88

4

20

Small-scale

0.701

High

905636

IRAK1
Interleukin-1 receptor-associated kinase 1

3

2

Small-scale

0.691

High

378240

IFNA1
Interferon alpha-1/13

4

20

Small-scale

0.683

High

623470

RO52
E3 ubiquitin-protein ligase TRIM21

4

9

Small-scale

0.683

High

1368450

CBP
CREB-binding protein

1

17

Small-scale

0.647

High

414346

P53
Cellular tumor antigen p53

3

4

Small-scale

0.642

High

378257

IFNA2
Interferon alpha-2

3

20

Small-scale

0.640

High

1045603

TF65
Transcription factor p65

3

20

Small-scale

0.640

High

124821

AIP
AH receptor-interacting protein

2

5

Small-scale

0.639

High

1014573

SMAD3
Mothers against decapentaplegic homolog 3

2

4

Small-scale

0.639

High

1100193

TIF1B
Transcription intermediary factor 1-beta

2

13

Small-scale

0.634

High

1371144

TBK1
Serine/threonine-protein kinase TBK1

2

14

Small-scale

0.614

High

521402

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.586

High

1288355

TLK2
Serine/threonine-protein kinase tousled-like 2

1

3

High-throughput

0.586

High

390400

CXL10
C-X-C motif chemokine 10

2

10

Small-scale

0.584

High

1101233

NMI
N-myc-interactor

2

2

Small-scale

0.584

High

1122536

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

14

Small-scale

0.584

High

1306873

IFNL1
Interferon lambda-1

2

7

Small-scale

0.584

High

1106640

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.578

High

1153860

SMAD2
Mothers against decapentaplegic homolog 2

1

4

Small-scale

0.578

High

97275

E9PSE3
Interferon regulatory factor 7

1

17

High-throughput

0.575

High

317902

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.561

High

1371147

PALD
Paladin

1

0

High-throughput

0.561

High

155959

SOCS3
Suppressor of cytokine signaling 3

1

7

Small-scale

0.561

High

193294

SOCS1
Suppressor of cytokine signaling 1

1

8

Small-scale

0.561

High

1369459

TANK
TRAF family member-associated NF-kappa-B activator

1

2

Small-scale

0.552

High

439812

INSR
Insulin receptor

1

1

High-throughput

0.541

High

401248

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.536

High

610812

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.536

High

821490

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.536

High

861241

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.536

High

868224

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

876102

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.536

High

881265

FAS
Fatty acid synthase

1

1

High-throughput

0.536

High

882074

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.536

High

899166

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.536

High

899511

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.536

High

911036

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.536

High

914107

HXK2
Hexokinase-2

1

3

High-throughput

0.536

High

1007184

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.536

High

1094793

CAF1B
Chromatin assembly factor 1 subunit B

1

1

High-throughput

0.536

High

1108650

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.536

High

1118546

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.536

High

1315564

HACE1
E3 ubiquitin-protein ligase HACE1

1

2

High-throughput

0.536

High

1316042

TRM2A
tRNA

1

1

High-throughput

0.536

High

1371136

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.536

High

1371131

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.535

High

1324577

PIAS4
E3 SUMO-protein ligase PIAS4

1

3

Small-scale

0.534

High

593000

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.518

High

873745

GSH0
Glutamate--cysteine ligase regulatory subunit

1

0

High-throughput

0.518

High

639280

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

Small-scale

0.515

High

1278055

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.515

High

1371152

MAFB
Transcription factor MafB

1

3

Small-scale

0.515

High

697610

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.513

High

921739

COPB
Coatomer subunit beta

1

0

High-throughput

0.513

High

1123999

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

1138471

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.513

High

1231857

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.513

High

1371138

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.513

High

1371143

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.513

High

1371149

VPS4A
Vacuolar protein sorting-associated protein 4A

1

0

High-throughput

0.513

High

1371150

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.513

High

1369192

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.501

High

280425

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

3

Small-scale

0.479

High

345097

RIGI
Antiviral innate immune response receptor RIG-I

1

7

Small-scale

0.479

High

378274

IFNA7
Interferon alpha-7

1

20

Small-scale

0.479

High

425594

ISG15
Ubiquitin-like protein ISG15

1

10

Small-scale

0.479

High

562904

CCL5
C-C motif chemokine 5

1

10

Small-scale

0.479

High

587169

ITF2
Transcription factor 4

1

1

Small-scale

0.479

High

626314

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.479

High

712734

IL12A
Interleukin-12 subunit alpha

1

7

Small-scale

0.479

High

714323

PML
Protein PML

1

14

Small-scale

0.479

High

723036

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

832761

BCL6
B-cell lymphoma 6 protein

1

5

Small-scale

0.479

High

842821

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

Small-scale

0.479

High

897928

CDK9
Cyclin-dependent kinase 9

1

1

Small-scale

0.479

High

946672

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

1005625

PITX1
Pituitary homeobox 1

1

1

Small-scale

0.479

High

1061605

FOXM1
Forkhead box protein M1

1

4

Small-scale

0.479

High

1096917

FADD
FAS-associated death domain protein

1

4

Small-scale

0.479

High

1106367

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

20

Small-scale

0.479

High

1109640

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

Small-scale

0.479

High

1109958

HDAC1
Histone deacetylase 1

1

5

Small-scale

0.479

High

1117291

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

Small-scale

0.479

High

1292852

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.479

High

1307140

TCAM1
TIR domain-containing adapter molecule 1

1

2

Small-scale

0.479

High

1316503

IFNL3
Interferon lambda-3

1

7

Small-scale

0.479

High

1371133

RNF31
E3 ubiquitin-protein ligase RNF31

1

3

Small-scale

0.479

High

1371135

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

1371142

CXXC1
CXXC-type zinc finger protein 1

1

3

Small-scale

0.479

High

168304

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

600351

ZNF24
Zinc finger protein 24

1

0

Small-scale

0.458

High

669965

MCM3
DNA replication licensing factor MCM3

1

0

Small-scale

0.458

High

1097464

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.458

High

1150679

TRBP2
RISC-loading complex subunit TARBP2

1

0

Small-scale

0.458

High

1153570

MLF2
Myeloid leukemia factor 2

1

0

Small-scale

0.458

High

1371132

NEUL3
E3 ubiquitin-protein ligase NEURL3

1

0

Small-scale

0.458

High

1371134

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.458

High

1371139

NDC1
Nucleoporin NDC1

1

0

Small-scale

0.458

High

1371141

FACD2
Fanconi anemia group D2 protein

1

0

Small-scale

0.458

High

1371145

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

Small-scale

0.458

High

1371146

BAG5
BAG family molecular chaperone regulator 5

1

0

Small-scale

0.458

High

990979

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

High-throughput

0.457

High

91565

C9J4M6
DNA-directed RNA polymerase subunit beta

1

1

High-throughput

0.445

High

177922

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

15

Small-scale

0.445

High

530175

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.445

High

1218348

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

1371148

ALK
ALK tyrosine kinase receptor

1

1

Small-scale

0.437

High

703016

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.426

High

839064

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

1371140

TR61B
tRNA

2

0

High-throughput

0.339

High

567047

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

106403

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025