HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007165 - signal transduction GO:0030336 - negative regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 196
+	Hs
		876341 AFAD_HUMAN (1-1824): 0: 1279: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		925728 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		894114 RAIN_HUMAN (244-982): 5.22e-96: 336: 16.01		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		925290 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900489 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915687 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545389 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436312 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		951007 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		892382 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894027 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564536 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120447 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		951362 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		1336631 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		V9HWD0_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		564695 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Mm
		925797 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10
+	Mm
		1111996 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		Q3TLP8_MOUSE (1-196): 9.48e-75: 225: 49.77
+	Hs
		892525 DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		564636 DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74