HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007165 - signal transduction GO:0030054 - cell junction GO:0030336 - negative regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1919
+	Hs
		876372 AFAD_HUMAN (1-1824): 0: 1279: 100.00		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		876529 AFAD_HUMAN (1-1824): 0: 1279: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		876370 AFAD_HUMAN (1-1824): 0: 1279: 100.00		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		876368 AFAD_HUMAN (1-1824): 0: 1279: 100.00		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Dm
		1214096 Q8IPP3_DROME (1-1732): 0: 876: 31.05		Q9VHK4_DROME (1359-1806): 8.75e-21: 102: 12.90
+	Dm
		51907 A1Z6Z9_DROME (102-924): 1.68e-103: 370: 14.56		M9PJD0_DROME (1155-1919): 3.9e-111: 395: 15.10
+	Hs
		1021567 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		942384 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		DLG4_HUMAN (1177-1916): 3.58e-156: 499: 20.46
+	Mm
		93501 E9Q4K7_MOUSE (184-691): 6.04e-63: 240: 12.41		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		1021494 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Rn
		292061 KIF1B_RAT (314-589): 6.15e-42: 171: 18.09		DLG1_RAT (1120-1916): 6.2e-163: 524: 21.03
+	Dm
		54780 A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76		DLG1_DROME (1123-1916): 3.18e-132: 441: 20.16
+	Rn
		292059 KIF1B_RAT (314-589): 6.15e-42: 171: 18.09		DLG4_RAT (1177-1916): 6.4e-157: 502: 20.58
+	Ce
		619838 UN104_CAEEL (183-614): 6.37e-75: 279: 16.34		LIN2_CAEEL (1235-1919): 3.77e-105: 363: 14.77
+	Hs
		1066234 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		1066390 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PALS1_HUMAN (1501-1916): 9.35e-98: 333: 19.50
+	Dm
		1096983 Q24279_DROME (639-1315): 3.98e-97: 351: 38.74		Q7K4E2_DROME (1164-1806): 6.4e-21: 102: 11.97
+	Hs
		280044 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		MPDZ_HUMAN (1405-1909): 9.74e-18: 92.7: 11.22
+	Hs
		1066824 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		990843 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81