Protein: NISCH
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)

Gene: NISCH
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q9Y2I1

Gene Ontology (top 5):
GO:0005178 - integrin binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384974

SGK3
Serine/threonine-protein kinase Sgk3

1

5

High-throughput

0.691

High

1243439

CNKR3
Connector enhancer of kinase suppressor of ras 3

4

1

High-throughput

0.691

High

699904

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

4

3

High-throughput

0.683

High

957561

UBC12
NEDD8-conjugating enzyme Ubc12

3

2

High-throughput

0.667

High

1114698

CUL3
Cullin-3

3

9

High-throughput

0.656

High

902150

RAB9A
Ras-related protein Rab-9A

3

19

Small-scale

0.655

High

1105192

U119A
Protein unc-119 homolog A

2

1

High-throughput

0.628

High

1351545

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.628

High

1364898

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

9

High-throughput

0.628

High

772532

IRS1
Insulin receptor substrate 1

1

9

Small-scale

0.618

High

1434271

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

1490754

NISCH
Nischarin

1

19

Small-scale

0.618

High

1490758

IRS2
Insulin receptor substrate 2

1

6

Small-scale

0.618

High

160651

IRS4
Insulin receptor substrate 4

2

3

Small-scale

0.611

High

190522

COPT1
High affinity copper uptake protein 1

2

2

High-throughput

0.601

High

968837

PRS4
26S proteasome regulatory subunit 4

2

1

High-throughput

0.601

High

1006960

KC1G2
Casein kinase I isoform gamma-2

2

5

High-throughput

0.601

High

1451500

GID8
Glucose-induced degradation protein 8 homolog

2

1

High-throughput

0.601

High

1429403

SPRTN
DNA-dependent metalloprotease SPRTN

2

0

High-throughput

0.585

High

540767

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.584

High

710582

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.584

High

978417

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

1108890

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

2

0

High-throughput

0.576

High

1370593

FGF11
Fibroblast growth factor 11

2

0

High-throughput

0.576

High

1415068

ZN747
Zinc finger protein 747

2

7

High-throughput

0.549

High

341222

VATG2
V-type proton ATPase subunit G 2

2

0

High-throughput

0.547

High

771090

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

6

High-throughput

0.541

High

1399292

CLIC6
Chloride intracellular channel protein 6

1

1

High-throughput

0.541

High

136452

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

11

High-throughput

0.536

High

193832

PER1
Period circadian protein homolog 1

1

3

High-throughput

0.536

High

788824

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

972156

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.536

High

988049

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.536

High

990892

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.536

High

1310536

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1436392

MANS1
MANSC domain-containing protein 1

1

1

High-throughput

0.536

High

1462007

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.536

High

1490760

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

1123555

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

50296

ODAM
Odontogenic ameloblast-associated protein

1

0

High-throughput

0.513

High

833445

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.513

High

1430006

SHRPN
Sharpin

1

0

High-throughput

0.513

High

186137

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

1016299

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.493

High

288147

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

1322371

ZN444
Zinc finger protein 444

1

5

High-throughput

0.489

High

1392758

ZN764
Zinc finger protein 764

1

8

High-throughput

0.489

High

1394364

ZN414
Zinc finger protein 414

1

1

High-throughput

0.489

High

1490755

KLH20
Kelch-like protein 20

1

6

Small-scale

0.481

High

126883

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

218986

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

294551

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

299436

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

341177

DIRA3
GTP-binding protein Di-Ras3

1

10

High-throughput

0.479

High

364059

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

374293

RASN
GTPase NRas

1

20

High-throughput

0.479

High

376120

RASK
GTPase KRas

1

20

High-throughput

0.479

High

390821

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.479

High

412841

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

439884

INSR
Insulin receptor

1

20

High-throughput

0.479

High

440252

LCK
Tyrosine-protein kinase Lck

1

6

High-throughput

0.479

High

463854

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

465696

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

541769

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

562499

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

581380

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601508

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

604280

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

631030

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.479

High

631576

RAB5A
Ras-related protein Rab-5A

1

9

High-throughput

0.479

High

648748

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

693143

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

710671

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.479

High

710775

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.479

High

710920

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.479

High

769556

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

884422

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

901690

RAB7A
Ras-related protein Rab-7a

1

12

High-throughput

0.479

High

910261

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

930089

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

931918

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.479

High

932158

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.479

High

942968

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.479

High

953767

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955768

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956550

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.479

High

962647

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962863

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975332

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

976680

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

988840

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1004245

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.479

High

1015917

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1034385

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

1041383

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1103460

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.479

High

1145182

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

1146495

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.479

High

1147469

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.479

High

1151940

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1157120

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

1159558

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1159913

OCLN
Occludin

1

1

High-throughput

0.479

High

1185957

PCGF3
Polycomb group RING finger protein 3

1

3

High-throughput

0.479

High

1197605

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

5

High-throughput

0.479

High

1233591

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1235351

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.479

High

1249347

LMBRL
Protein LMBR1L

1

4

High-throughput

0.479

High

1256166

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1270449

SND1
Staphylococcal nuclease domain-containing protein 1

1

3

High-throughput

0.479

High

1271061

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1286275

PCGF5
Polycomb group RING finger protein 5

1

2

High-throughput

0.479

High

1323051

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1329956

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1360850

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.479

High

1364716

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1366920

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1367630

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1368533

CBP
CREB-binding protein

1

7

High-throughput

0.479

High

1407795

ARI3A
AT-rich interactive domain-containing protein 3A

1

4

High-throughput

0.479

High

1416705

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

19

High-throughput

0.479

High

1417941

K1671
Uncharacterized protein KIAA1671

1

1

High-throughput

0.479

High

1433011

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1433588

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1435477

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.479

High

1438253

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1461312

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

1462780

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.479

High

1490759

ARI1
E3 ubiquitin-protein ligase ARIH1

1

10

High-throughput

0.479

High

822913

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

297884

PIAS2
E3 SUMO-protein ligase PIAS2

1

0

High-throughput

0.458

High

516788

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

896474

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.458

High

1308616

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.458

High

1383285

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1433808

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

1448127

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1490757

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

714532

PML
Protein PML

1

5

High-throughput

0.445

High

844900

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.445

High

845165

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.445

High

876450

EAA4
Excitatory amino acid transporter 4

1

3

High-throughput

0.445

High

943562

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

1

High-throughput

0.445

High

1094447

CSN1
COP9 signalosome complex subunit 1

1

1

High-throughput

0.445

High

1094660

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.445

High

1133822

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.445

High

1288176

SL9B2
Sodium/hydrogen exchanger 9B2

1

4

High-throughput

0.445

High

1310985

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.445

High

1490761

S4A7
Sodium bicarbonate cotransporter 3

1

3

High-throughput

0.445

High

76162

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

5

High-throughput

0.437

High

106884

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

124538

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

1253131

GCNT7
Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7

1

1

High-throughput

0.437

High

1382011

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1384552

Q96BE0
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.437

High

231820

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.426

High

654145

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.426

High

1238906

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.426

High

1339497

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.426

High

1389094

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.426

High

1416821

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

0

High-throughput

0.426

High

69846

ZN785
Zinc finger protein 785

1

6

High-throughput

0.407

High

653668

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

1330870

FRMD1
FERM domain-containing protein 1

1

5

High-throughput

0.407

High

1387427

ESS2
Splicing factor ESS-2 homolog

1

1

High-throughput

0.407

High

1461804

ABT1
Activator of basal transcription 1

2

0

High-throughput

0.313

High

477351

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

651611

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.279

Low

1211638

SPT46
Spermatogenesis-associated protein 46

1

0

High-throughput

0.279

Low

1220496

F219B
Protein FAM219B

1

0

High-throughput

0.279

Low

1313191

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.279

Low

1379841

LEAP2
Liver-expressed antimicrobial peptide 2

1

0

High-throughput

0.279

Low

1490756

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

377787

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1349640

DEN10
DENN domain-containing protein 10

1

0

High-throughput

0.249

Low

1451648

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

1237987

Q6NSK7
RIN3 protein

1

0

High-throughput

0.238

Low

377322

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

1

0

High-throughput

0.232

Low

1178921

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.232

Low

1307250

TF2LY
Homeobox protein TGIF2LY

1

0

High-throughput

0.232

Low

1308332

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.232

Low

1328047

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.232

Low

1334293

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1393020

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025