HitPredict

Interactor 1: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	30948266, 9384571, 16339151
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 604
+	Hs
		876945 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		788193 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Mm
		140026 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		BIRC3_MOUSE (3-604): 0: 662: 73.92
+	Hs
		788194 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		788252 CASP2_HUMAN (54-301): 2.1e-96: 293: 29.12		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		876939 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Mm
		957027 CASP7_MOUSE (1-303): 3.09e-159: 447: 82.18		XIAP_MOUSE (147-604): 9.05e-80: 262: 24.00
+	Hs
		788182 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Mm
		936913 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		XIAP_MOUSE (147-604): 9.05e-80: 262: 24.00
+	Hs
		876964 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC6_HUMAN (7-136): 3.42e-35: 144: 20.29
+	Hs
		877014 CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		876960 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC7_HUMAN (13-165): 1.87e-34: 134: 21.80
+	Rn
		1337442 Q9JHK1_RAT (53-301): 2.01e-97: 296: 31.66		XIAP_RAT (147-604): 5.81e-80: 262: 23.81
+	Hs
		177663 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC5_HUMAN (258-332): 1.39e-25: 104: 35.00
+	Hs
		788230 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC6_HUMAN (7-136): 3.42e-35: 144: 20.29
+	Hs
		788221 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC7_HUMAN (13-165): 1.87e-34: 134: 21.80
+	Hs
		177658 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC5_HUMAN (258-332): 1.39e-25: 104: 35.00
+	Dm
		136290 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP2_DROME (9-100): 4.66e-25: 110: 31.52
+	Dm
		136289 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP1_DROME (20-173): 1.43e-24: 108: 24.36
+	Dm
		137119 CASP1_DROME (20-302): 1.17e-105: 312: 39.72		DIAP1_DROME (20-173): 1.43e-24: 108: 24.36