HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.995

The method score is based on:

Property Details
Experiments 25416956, 15069192, 16189514, 29997244, 30522111, 32296183, 9545235, 15749826, 14523016, 15300255, 18022362, 11801603, 15507451, 16701639, 19153467, 12620238, 17179183, 17291493, 14512414, 19698783 and 15 others

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Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, pull down, enzymatic study, unspecified method, x-ray crystallography, far western blotting, cosedimentation in solution, biochemical and 9 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~zf-C3HC4_3, BIR~Peptidase_C14
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0051402 - neuron apoptotic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 416
Hs

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Last updated: 15 Jul 2024