Protein: NLRP3
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)

Gene: NLRP3
Organism: Mus musculus
Interactions: 47
UniProt ID: Q8R4B8

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002526 - acute inflammatory response
GO:0002720 - positive regulation of cytokine production involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1341594

ASC
Apoptosis-associated speck-like protein containing a CARD

13

17

Small-scale

0.974

High

1341595

NEK7
Serine/threonine-protein kinase Nek7

5

3

Small-scale

0.906

High

1044578

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

7

Small-scale

0.665

High

1296860

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.618

High

1341590

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

17

Small-scale

0.618

High

1341596

FLII
Protein flightless-1 homolog

1

7

Small-scale

0.618

High

1341591

MAVS
Mitochondrial antiviral-signaling protein

2

2

Small-scale

0.601

High

858826

BRCC3
Lys-63-specific deubiquitinase BRCC36

2

4

Small-scale

0.584

High

1225666

SQSTM
Sequestosome-1

2

5

Small-scale

0.584

High

1341597

AMFR
E3 ubiquitin-protein ligase AMFR

1

3

Small-scale

0.561

High

1341598

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

2

Small-scale

0.561

High

1341599

PRKN
E3 ubiquitin-protein ligase parkin

1

13

Small-scale

0.561

High

1208537

DIRA2
GTP-binding protein Di-Ras2

1

5

Small-scale

0.553

High

712516

CASP1
Caspase-1

1

20

Small-scale

0.515

High

59876

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

2

Small-scale

0.479

High

99231

HERC6
E3 ISG15--protein ligase Herc6

1

5

Small-scale

0.479

High

205533

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.479

High

618934

GSTP1
Glutathione S-transferase P 1

1

3

Small-scale

0.479

High

627486

BIP
Endoplasmic reticulum chaperone BiP

1

13

Small-scale

0.479

High

661046

IRF8
Interferon regulatory factor 8

1

7

High-throughput

0.479

High

832243

RL28
Large ribosomal subunit protein eL28

1

2

Small-scale

0.479

High

944879

PCBP3
Poly(rC)-binding protein 3

1

6

Small-scale

0.479

High

986937

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

1189586

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.479

High

1189993

Q3UCL2
E3 ubiquitin-protein ligase TRIM21

1

13

Small-scale

0.479

High

1190498

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1209914

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

6

Small-scale

0.479

High

1224070

TIF1B
Transcription intermediary factor 1-beta

1

8

Small-scale

0.479

High

1274295

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

Small-scale

0.479

High

1283501

TRI50
E3 ubiquitin-protein ligase TRIM50

1

14

Small-scale

0.479

High

1295866

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1295881

ACTBL
Beta-actin-like protein 2

1

2

Small-scale

0.479

High

1295928

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

1297475

TRI14
Tripartite motif-containing protein 14

1

20

Small-scale

0.479

High

1297676

TRI47
E3 ubiquitin-protein ligase TRIM47

1

20

Small-scale

0.479

High

1341458

TRI31
E3 ubiquitin-protein ligase TRIM31

1

17

Small-scale

0.479

High

1341593

RN125
E3 ubiquitin-protein ligase RNF125

1

17

Small-scale

0.479

High

1283535

MFN1
Mitofusin-1

1

0

Small-scale

0.458

High

1341592

RFIP1
Rab11 family-interacting protein 1

1

0

Small-scale

0.458

High

1341600

NFS1
Cysteine desulfurase

1

0

Small-scale

0.458

High

1341601

CLIC1
Chloride intracellular channel protein 1

1

0

Small-scale

0.458

High

869553

KSYK
Tyrosine-protein kinase SYK

1

5

Small-scale

0.445

High

940746

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

3

Small-scale

0.437

High

1221208

MYL6
Myosin light polypeptide 6

1

4

Small-scale

0.437

High

1234179

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

1298109

Q8C788
Sorting nexin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025