HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.980

The method score is based on:

Property Details
Experiments 27197231, 25416956, 15069192, 32296183, 9545235, 16339151, 16701639, 19153467, 11084335, 31515488, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, pull down, x-ray crystallography, unspecified method, validated two hybrid, two hybrid array, anti tag coimmunoprecipitation, surface plasmon resonance, two hybrid prey pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, CARD~zf-C3HC4_3, BIR~Peptidase_C14
Common GO terms GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 416
Hs

1 618
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Last updated: 15 Jul 2024