HitPredict

Interactor 1: D2IYK1 (D2IYK1)
HLA class I histocompatibility antigen B alpha chain (MHC class I antigen) (MHC class I protein)
Gene: HLA-B

Interactor 2: KI2L3 (P43628)
Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)
Gene: KIR2DL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18322206
Identification Methods	affinity chromatography technology
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~ig, MHC_I~ig
Common GO terms	GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 362 Hs			1 341
+	Hs
		798195 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI2L3_HUMAN (1-341): 4.64e-132: 381: 100.00
+	Hs
		798280 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI2S4_HUMAN (1-304): 2.2e-122: 356: 88.16
+	Hs
		798194 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L3_HUMAN (1-341): 4.64e-132: 381: 100.00
+	Hs
		798173 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L2_HUMAN (1-340): 4.85e-129: 374: 94.41
+	Hs
		798148 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L1_HUMAN (1-340): 1.84e-126: 368: 90.59
+	Hs
		798171 Q5D1W8_HUMAN (1-362): 7.73e-165: 466: 86.50		KI2L2_HUMAN (1-340): 4.85e-129: 374: 94.41
+	Hs
		798146 Q5D1W8_HUMAN (1-362): 7.73e-165: 466: 86.50		KI2L1_HUMAN (1-340): 1.84e-126: 368: 90.59
+	Hs
		1060406 Q95J06_HUMAN (1-362): 0: 510: 84.53		KI3S1_HUMAN (1-251): 4.28e-63: 206: 37.80
+	Hs
		47499 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		A0A8I5QEB2_HUMAN (1-246): 8.95e-66: 214: 41.77
+	Hs
		382420 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		KI3S1_HUMAN (1-251): 4.28e-63: 206: 37.80
+	Hs
		382341 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		KI3L2_HUMAN (1-246): 1.73e-61: 205: 40.56
+	Hs
		798244 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI3L2_HUMAN (1-246): 1.73e-61: 205: 40.56
+	Hs
		1060403 Q5SUL5_HUMAN (1-362): 9.11e-176: 494: 84.53		KI3S1_HUMAN (1-251): 4.28e-63: 206: 37.80
+	Hs
		1232786 Q95J06_HUMAN (1-362): 0: 510: 84.53		LIRB2_HUMAN (17-341): 1.02e-45: 165: 30.56
+	Hs
		382478 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB2_HUMAN (17-341): 1.02e-45: 165: 30.56
+	Hs
		1130837 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		LIRB2_HUMAN (17-341): 1.02e-45: 165: 30.56
+	Hs
		382484 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB4_HUMAN (17-337): 4.91e-30: 120: 24.22
+	Hs
		1245576 Q95J06_HUMAN (1-362): 0: 510: 84.53		LIRB1_HUMAN (278-337): 8.29e-10: 61.8: 25.00
+	Hs
		382485 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB1_HUMAN (278-337): 8.29e-10: 61.8: 25.00
+	Hs
		1130838 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		LIRB1_HUMAN (278-337): 8.29e-10: 61.8: 25.00