HitPredict

Interactor 1: SUMO3 (P55854)
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Gene: SUMO3

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	35914814, 18538659
Identification Methods	two hybrid, pull down, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1055
+	Hs
		902795 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		928224 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		902725 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP28_HUMAN (1-1047): 0: 894: 48.57
+	Hs
		800569 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP5_HUMAN (148-656): 1.28e-85: 297: 15.09
+	Hs
		902707 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		902655 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP48_HUMAN (157-406): 1.37e-66: 245: 25.86
+	Hs
		902708 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		902780 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		UBP36_HUMAN (560-684): 1.95e-11: 70.7: 22.84