Protein: P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)

Gene: P5CR1, PYCR1
Organism: Homo sapiens
Interactions: 201
UniProt ID: P32322

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0034599 - cellular response to oxidative stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733974

P5CR2
Pyrroline-5-carboxylate reductase 2

4

14

High-throughput

0.895

High

733940

P5CR3
Pyrroline-5-carboxylate reductase 3

3

14

High-throughput

0.861

High

733886

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

14

Small-scale

0.789

High

733892

HSPA9
Stress-70 protein, mitochondrial

3

3

High-throughput

0.656

High

66139

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

1

High-throughput

0.611

High

470877

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

1

High-throughput

0.611

High

733898

IF2M
Translation initiation factor IF-2, mitochondrial

2

2

High-throughput

0.611

High

733950

KLD10
Kelch domain-containing protein 10

3

1

High-throughput

0.609

High

734028

NUDT5
ADP-sugar pyrophosphatase

3

1

High-throughput

0.609

High

240879

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

279670

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

403863

GCR
Glucocorticoid receptor

2

2

Small-scale

0.584

High

559884

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

1

High-throughput

0.584

High

733918

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

733937

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

734012

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

3

Small-scale

0.578

High

733929

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

7

Small-scale

0.571

High

733957

LCA5
Lebercilin

2

2

High-throughput

0.571

High

734030

RHG26
Rho GTPase-activating protein 26

2

2

High-throughput

0.571

High

326664

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.558

High

733943

CE162
Centrosomal protein of 162 kDa

2

2

High-throughput

0.537

High

166759

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.536

High

733923

CUL3
Cullin-3

1

2

High-throughput

0.536

High

733970

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

2

High-throughput

0.536

High

371293

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

733899

PAXI
Paxillin

2

1

High-throughput

0.521

High

733952

SYDE1
Rho GTPase-activating protein SYDE1

2

5

High-throughput

0.521

High

733961

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.521

High

177518

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

716098

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

733902

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.513

High

733989

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

733967

CBP
CREB-binding protein

1

2

Small-scale

0.512

High

733987

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.512

High

733901

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.494

High

138910

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

1

High-throughput

0.489

High

729156

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

4

High-throughput

0.489

High

733903

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

4

High-throughput

0.489

High

733920

CDC16
Cell division cycle protein 16 homolog

1

4

High-throughput

0.489

High

733976

APC16
Anaphase-promoting complex subunit 16

1

1

High-throughput

0.489

High

734025

CDC23
Cell division cycle protein 23 homolog

1

4

High-throughput

0.489

High

734026

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.489

High

734027

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.489

High

61439

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

183594

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

216636

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

281897

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287245

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

296202

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

347551

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

348384

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

350800

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

361609

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

411451

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

519058

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532397

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

733890

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

733893

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

733894

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

733897

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

733909

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

733911

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

733913

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

733914

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

733916

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

733917

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

733919

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

733924

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

733927

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

733933

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

733934

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

733941

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

733946

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

733948

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

733949

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.479

High

733953

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

733954

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

733958

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.479

High

733962

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

733969

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

5

High-throughput

0.479

High

733971

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

733972

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

733973

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

733975

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

733977

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

733978

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

733980

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

733982

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

733983

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

733984

EFGM
Elongation factor G, mitochondrial

1

5

High-throughput

0.479

High

733985

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.479

High

733990

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

733991

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

733992

TR61B
tRNA

1

1

High-throughput

0.479

High

733993

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

733994

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

733998

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

733999

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

734002

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

734003

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

734004

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

734005

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

734006

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

734007

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

734008

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

734010

NGRN
Neugrin

1

1

High-throughput

0.479

High

734013

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

734014

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

734015

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

734017

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

734018

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

734019

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

734021

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

734022

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

734031

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

734033

DJC15
DnaJ homolog subfamily C member 15

1

2

High-throughput

0.479

High

733960

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

1

High-throughput

0.470

High

400374

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

733906

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

943

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

529198

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

733942

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

734001

5NT3A
Cytosolic 5'-nucleotidase 3A

1

1

High-throughput

0.445

High

734035

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

175847

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.437

High

293276

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

315188

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

583822

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

650064

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

730998

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.437

High

733887

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.437

High

733889

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

733891

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.437

High

733895

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.437

High

733896

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

733900

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

733905

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.437

High

733907

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

733912

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.437

High

733915

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.437

High

733921

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.437

High

733922

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

733926

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

733928

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.437

High

733931

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.437

High

733935

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

733939

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.437

High

733944

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

733951

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

733956

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

733959

MILK2
MICAL-like protein 2

1

1

High-throughput

0.437

High

733963

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

733964

COP1
E3 ubiquitin-protein ligase COP1

1

6

High-throughput

0.437

High

733965

DEP1B
DEP domain-containing protein 1B

1

2

High-throughput

0.437

High

733966

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.437

High

733968

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.437

High

733986

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.437

High

734020

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

734023

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

734029

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.437

High

127640

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.407

High

163494

ZN213
Zinc finger protein 213

1

1

High-throughput

0.407

High

619544

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

733995

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.407

High

164537

TNPO2
Transportin-2

2

0

High-throughput

0.316

High

531009

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.298

High

717248

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

62911

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.279

Low

733888

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

733904

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.279

Low

733947

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

733979

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

734024

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

734034

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

228188

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.265

Low

299468

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

0

High-throughput

0.265

Low

733925

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

733955

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

0

High-throughput

0.251

Low

157003

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

417970

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

536604

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

565184

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

623139

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.249

Low

733908

DAB2
Disabled homolog 2

1

0

Small-scale

0.249

Low

733910

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

733930

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

733932

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

733936

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

733938

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

733945

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

733981

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

733988

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.249

Low

733997

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

734009

MYO10
Unconventional myosin-X

1

0

Small-scale

0.249

Low

734011

ANLN
Anillin

1

0

High-throughput

0.249

Low

734016

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

734032

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

429382

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

733996

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

734000

SC5A7
High affinity choline transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025