HitPredict

Interactor 1: BID (P55957)
BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]
Gene: BID

Interactor 2: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 20956295, 17289999, 23374347
Identification Methods anti bait coimmunoprecipitation, surface plasmon resonance, anti tag coimmunoprecipitation, x-ray crystallography
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BID~Bcl-2
Common GO terms GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
and 7 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 195
Hs

1 192
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024