Protein: RXRA
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)

Gene: RXRA
Organism: Homo sapiens
Interactions: 147
UniProt ID: P19793

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625774

PPARG
Peroxisome proliferator-activated receptor gamma

36

20

Small-scale

0.994

High

543456

VDR
Vitamin D3 receptor

27

20

Small-scale

0.992

High

520510

RARA
Retinoic acid receptor alpha

21

17

Small-scale

0.989

High

625823

NCOA1
Nuclear receptor coactivator 1

15

20

Small-scale

0.983

High

533320

THB
Thyroid hormone receptor beta

9

20

Small-scale

0.968

High

625800

PPARA
Peroxisome proliferator-activated receptor alpha

7

20

Small-scale

0.953

High

625819

NCOA2
Nuclear receptor coactivator 2

5

20

Small-scale

0.922

High

625788

NR1H2
Oxysterols receptor LXR-beta

5

20

Small-scale

0.922

High

625797

PPARD
Peroxisome proliferator-activated receptor delta

5

20

Small-scale

0.912

High

625807

NR1H3
Oxysterols receptor LXR-alpha

4

20

Small-scale

0.891

High

625816

NR1I3
Nuclear receptor subfamily 1 group I member 3

4

20

Small-scale

0.888

High

625858

NCOA3
Nuclear receptor coactivator 3

4

20

Small-scale

0.888

High

282921

NR1I2
Nuclear receptor subfamily 1 group I member 2

4

20

Small-scale

0.881

High

533245

THA
Thyroid hormone receptor alpha

4

19

Small-scale

0.875

High

625761

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

3

20

Small-scale

0.856

High

625756

RXRA
Retinoic acid receptor RXR-alpha

3

20

Small-scale

0.840

High

625818

NR0B2
Nuclear receptor subfamily 0 group B member 2

3

19

Small-scale

0.833

High

625840

NR1H4
Bile acid receptor

2

20

Small-scale

0.821

High

625780

RXRG
Retinoic acid receptor RXR-gamma

2

20

High-throughput

0.811

High

625779

NR4A2
Nuclear receptor subfamily 4 group A member 2

2

20

Small-scale

0.786

High

625769

CTNB1
Catenin beta-1

2

17

Small-scale

0.754

High

625814

NCOA6
Nuclear receptor coactivator 6

6

20

Small-scale

0.738

High

625820

MED1
Mediator of RNA polymerase II transcription subunit 1

5

20

Small-scale

0.705

High

625857

NCOR2
Nuclear receptor corepressor 2

5

20

Small-scale

0.702

High

180700

TIF1A
Transcription intermediary factor 1-alpha

3

20

Small-scale

0.655

High

278233

NCOR1
Nuclear receptor corepressor 1

3

20

Small-scale

0.655

High

625855

NR2E3
Photoreceptor-specific nuclear receptor

1

20

Small-scale

0.647

High

625849

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

20

Small-scale

0.628

High

467774

MCR
Mineralocorticoid receptor

1

20

High-throughput

0.621

High

522768

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

19

Small-scale

0.621

High

543559

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.621

High

565506

RARG
Retinoic acid receptor gamma

1

17

High-throughput

0.621

High

395475

ESR1
Estrogen receptor

1

19

High-throughput

0.618

High

403810

GCR
Glucocorticoid receptor

1

19

Small-scale

0.618

High

625772

FUS
RNA-binding protein FUS

2

20

Small-scale

0.611

High

576159

PO2F1
POU domain, class 2, transcription factor 1

2

20

Small-scale

0.602

High

625781

NRIP1
Nuclear receptor-interacting protein 1

2

14

Small-scale

0.602

High

625799

TF65
Transcription factor p65

2

17

Small-scale

0.602

High

154938

BHE40
Class E basic helix-loop-helix protein 40

2

3

Small-scale

0.601

High

625762

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

2

6

Small-scale

0.600

High

464801

SP1
Transcription factor Sp1

2

20

Small-scale

0.595

High

625809

SQSTM
Sequestosome-1

2

8

Small-scale

0.595

High

625794

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.594

High

625831

MED25
Mediator of RNA polymerase II transcription subunit 25

1

7

Small-scale

0.594

High

625763

MK03
Mitogen-activated protein kinase 3

2

13

Small-scale

0.585

High

625835

ROBO4
Roundabout homolog 4

1

7

Small-scale

0.579

High

533212

RARB
Retinoic acid receptor beta

1

17

Small-scale

0.575

High

625776

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

12

High-throughput

0.573

High

258422

EDF1
Endothelial differentiation-related factor 1

1

2

Small-scale

0.561

High

284795

TADA3
Transcriptional adapter 3

1

4

Small-scale

0.561

High

609860

IBP3
Insulin-like growth factor-binding protein 3

1

2

Small-scale

0.561

High

625813

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.561

High

302368

RNF8
E3 ubiquitin-protein ligase RNF8

1

10

Small-scale

0.549

High

625803

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

625846

UBQL4
Ubiquilin-4

1

12

High-throughput

0.541

High

325682

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

Small-scale

0.536

High

65850

CAST2
Cytosolic arginine sensor for mTORC1 subunit 2

1

1

High-throughput

0.536

High

625834

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

1

1

High-throughput

0.536

High

625848

MIOS
GATOR2 complex protein MIOS

1

12

High-throughput

0.536

High

625764

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

Small-scale

0.534

High

192898

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.527

High

625758

TBP
TATA-box-binding protein

1

3

Small-scale

0.527

High

625760

BCL3
B-cell lymphoma 3 protein

1

20

Small-scale

0.527

High

625808

CENPR
Centromere protein R

1

1

Small-scale

0.527

High

625812

NCOA4
Nuclear receptor coactivator 4

1

1

Small-scale

0.527

High

625821

TRIP4
Activating signal cointegrator 1

1

4

Small-scale

0.527

High

625822

IKBB
NF-kappa-B inhibitor beta

1

15

Small-scale

0.527

High

625841

NPAS2
Neuronal PAS domain-containing protein 2

1

20

Small-scale

0.527

High

625844

BRD8
Bromodomain-containing protein 8

1

20

Small-scale

0.527

High

63955

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

Small-scale

0.508

High

625777

CASP2
Caspase-2

1

3

High-throughput

0.508

High

625783

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.508

High

625787

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.508

High

625796

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

625798

ARI5A
AT-rich interactive domain-containing protein 5A

1

20

Small-scale

0.508

High

625824

SMAD2
Mothers against decapentaplegic homolog 2

1

10

High-throughput

0.508

High

625825

SMN
Survival motor neuron protein

1

2

High-throughput

0.508

High

625842

KPCD2
Serine/threonine-protein kinase D2

1

10

High-throughput

0.508

High

625851

KS6A6
Ribosomal protein S6 kinase alpha-6

1

13

High-throughput

0.508

High

132699

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

20

Small-scale

0.501

High

188169

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.501

High

282352

MED24
Mediator of RNA polymerase II transcription subunit 24

1

4

Small-scale

0.501

High

332135

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

6

Small-scale

0.501

High

459219

CATL1
Procathepsin L

1

1

Small-scale

0.501

High

478901

PO2F2
POU domain, class 2, transcription factor 2

1

20

Small-scale

0.501

High

557079

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

Small-scale

0.501

High

581620

MYOD1
Myoblast determination protein 1

1

8

Small-scale

0.501

High

625757

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.501

High

625765

MK01
Mitogen-activated protein kinase 1

1

13

Small-scale

0.501

High

625766

PML
Protein PML

1

20

Small-scale

0.501

High

625782

CTCF
Transcriptional repressor CTCF

1

11

Small-scale

0.501

High

625791

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

625795

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.501

High

625810

TDG
G/T mismatch-specific thymine DNA glycosylase

1

2

Small-scale

0.501

High

625811

SNW1
SNW domain-containing protein 1

1

6

Small-scale

0.501

High

625828

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

2

Small-scale

0.501

High

625829

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

2

Small-scale

0.501

High

625830

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

18

Small-scale

0.501

High

625850

DNM3L
DNA

1

6

Small-scale

0.501

High

625852

GRIP1
Glutamate receptor-interacting protein 1

1

18

Small-scale

0.501

High

625853

ARIP4
Helicase ARIP4

1

20

Small-scale

0.501

High

625792

TMPS3
Transmembrane protease serine 3

1

3

High-throughput

0.494

High

625856

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

19

High-throughput

0.489

High

405396

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

186159

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

3

Small-scale

0.481

High

549283

SRF
Serum response factor

1

2

Small-scale

0.481

High

625767

GLPK
Glycerol kinase

1

2

High-throughput

0.481

High

625773

ACV1B
Activin receptor type-1B

1

1

High-throughput

0.481

High

625793

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

Small-scale

0.481

High

625838

NRBF2
Nuclear receptor-binding factor 2

1

1

Small-scale

0.481

High

625839

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

142829

NFIB
Nuclear factor 1 B-type

1

16

High-throughput

0.479

High

259428

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

447671

TPM3
Tropomyosin alpha-3 chain

1

10

High-throughput

0.479

High

473782

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

541328

FGFR1
Fibroblast growth factor receptor 1

1

3

Small-scale

0.479

High

557851

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

625759

LMNB1
Lamin-B1

1

18

High-throughput

0.479

High

625770

NOS2
Nitric oxide synthase, inducible

1

3

Small-scale

0.479

High

625771

MYH9
Myosin-9

1

9

High-throughput

0.479

High

625775

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

625778

MATR3
Matrin-3

1

11

High-throughput

0.479

High

625784

EMD
Emerin

1

1

High-throughput

0.479

High

625785

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

625786

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.479

High

625789

TERA
Transitional endoplasmic reticulum ATPase

1

8

Small-scale

0.479

High

625790

ANM2
Protein arginine N-methyltransferase 2

1

10

Small-scale

0.479

High

625801

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

625804

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

625805

TRAF2
TNF receptor-associated factor 2

1

15

Small-scale

0.479

High

625806

TRI32
E3 ubiquitin-protein ligase TRIM32

1

14

Small-scale

0.479

High

625815

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

625817

NONO
Non-POU domain-containing octamer-binding protein

1

20

High-throughput

0.479

High

625826

ZN423
Zinc finger protein 423

1

13

Small-scale

0.479

High

625827

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

20

Small-scale

0.479

High

625836

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

625837

REPS1
RalBP1-associated Eps domain-containing protein 1

1

5

High-throughput

0.479

High

625843

BHE41
Class E basic helix-loop-helix protein 41

1

8

Small-scale

0.479

High

625847

ZDH18
Palmitoyltransferase ZDHHC18

1

1

Small-scale

0.479

High

625854

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

625832

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

Small-scale

0.460

High

625845

PNRC2
Proline-rich nuclear receptor coactivator 2

1

15

Small-scale

0.457

High

443171

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.445

High

625802

KIF1A
Kinesin-like protein KIF1A

1

8

High-throughput

0.439

High

625768

CXCR5
C-X-C chemokine receptor type 5

1

7

Small-scale

0.437

High

625833

ZDH23
Palmitoyltransferase ZDHHC23

1

3

Small-scale

0.437

High


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Last updated: 11Aug2025